BPKDi [Ligand Id: 9370] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1214999
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
Created with Highcharts 10.3.3ValuesChart context menuBeta-1 adrenergic receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein kinase D1/Protein kinase C mu in Human [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
Created with Highcharts 10.3.3ValuesChart context menuProtein kinase C mupKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • protein kinase D2/Serine/threonine-protein kinase D2 in Human [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase D2pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • protein kinase D3 in Human [GtoPdb: 2174] [UniProtKB: O94806]
Created with Highcharts 10.3.3ValuesChart context menuprotein kinase D3pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL Inhibition of beta-1 adrenoceptor B 5.08 pIC50 8300 nM IC50 J Med Chem (2010) 53: 5422-5438 [PMID:20684592]
protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
GtoPdb In a biochemical enzyme assay. - 9 pIC50 1 nM IC50 FEBS Lett (2010) 584: 631-7 [PMID:20018189]
ChEMBL Inhibition of PKD1 by TR-FRET assay B 9 pIC50 1 nM IC50 J Med Chem (2010) 53: 5422-5438 [PMID:20684592]
ChEMBL Inhibition of PKD1 assessed as inhibition of HDAC5 neuclear export B 7.11 pEC50 77 nM EC50 J Med Chem (2010) 53: 5422-5438 [PMID:20684592]
protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6]
ChEMBL Inhibition of PKD2 by TR-FRET assay B 8.05 pIC50 9 nM IC50 J Med Chem (2010) 53: 5422-5438 [PMID:20684592]
GtoPdb In a biochemical enzyme assay. - 8.05 pIC50 9 nM IC50 FEBS Lett (2010) 584: 631-7 [PMID:20018189]
protein kinase D3 in Human [GtoPdb: 2174] [UniProtKB: O94806]
GtoPdb In a biochemical enzyme assay. - 9 pIC50 1 nM IC50 FEBS Lett (2010) 584: 631-7 [PMID:20018189]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]