BPKDi [Ligand Id: 9370] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1214999 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| ChEMBL | Inhibition of beta-1 adrenoceptor | B | 5.08 | pIC50 | 8300 | nM | IC50 | J Med Chem (2010) 53: 5422-5438 [PMID:20684592] |
| protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139] | ||||||||
| GtoPdb | In a biochemical enzyme assay. | - | 9 | pIC50 | 1 | nM | IC50 | FEBS Lett (2010) 584: 631-7 [PMID:20018189] |
| ChEMBL | Inhibition of PKD1 by TR-FRET assay | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2010) 53: 5422-5438 [PMID:20684592] |
| ChEMBL | Inhibition of PKD1 assessed as inhibition of HDAC5 neuclear export | B | 7.11 | pEC50 | 77 | nM | EC50 | J Med Chem (2010) 53: 5422-5438 [PMID:20684592] |
| protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6] | ||||||||
| ChEMBL | Inhibition of PKD2 by TR-FRET assay | B | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2010) 53: 5422-5438 [PMID:20684592] |
| GtoPdb | In a biochemical enzyme assay. | - | 8.05 | pIC50 | 9 | nM | IC50 | FEBS Lett (2010) 584: 631-7 [PMID:20018189] |
| protein kinase D3 in Human [GtoPdb: 2174] [UniProtKB: O94806] | ||||||||
| GtoPdb | In a biochemical enzyme assay. | - | 9 | pIC50 | 1 | nM | IC50 | FEBS Lett (2010) 584: 631-7 [PMID:20018189] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
