MELK-TI [Ligand Id: 9366] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3355059 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| maternal embryonic leucine zipper kinase/Maternal embryonic leucine zipper kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4578] [GtoPdb: 2102] [UniProtKB: Q14680] | ||||||||
| ChEMBL | Inhibition of MELK kinase (unknown origin) using KKLNRTLSFAEPG/gamma[33P]ATP by Millipore kinase/scintillation counting analysis | B | 4.64 | pIC50 | 23000 | nM | IC50 | ACS Med Chem Lett (2015) 6: 25-30 [PMID:25589925] |
| ChEMBL | Inhibition of MELK (unknown origin) | B | 6.7 | pIC50 | 200 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127202-127202 [PMID:32331933] |
| ChEMBL | Inhibition of MELK kinase (unknown origin) using biotinylated ZIP-tide peptide/gamma[33P]ATP by scintillation counting analysis | B | 7.43 | pIC50 | 37 | nM | IC50 | ACS Med Chem Lett (2015) 6: 25-30 [PMID:25589925] |
| ChEMBL | Inhibition of MELK (unknown origin) | B | 7.43 | pIC50 | 37 | nM | IC50 | ACS Med Chem Lett (2015) 6: 31-36 [PMID:25589926] |
| GtoPdb | Measured in a MIllipore kinase screening assay | - | 7.64 | pIC50 | 23 | nM | IC50 | ACS Med Chem Lett (2014) 6: 25-30 [PMID:25589925] |
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Inhibition of Flt3 (unknown origin) by Millipore kinase analysis | B | 4.74 | pIC50 | 18000 | nM | IC50 | ACS Med Chem Lett (2015) 6: 25-30 [PMID:25589925] |
| GtoPdb | Measured in a MIllipore kinase screening panel assay | - | 7.74 | pIC50 | 18 | nM | IC50 | ACS Med Chem Lett (2014) 6: 25-30 [PMID:25589925] |
| calcium/calmodulin-dependent protein kinase II delta subunit in Human [GtoPdb: 1558] [UniProtKB: Q13557] | ||||||||
| GtoPdb | Measured in a MIllipore kinase screening panel assay | - | 6.09 | pIC50 | 810 | nM | IC50 | ACS Med Chem Lett (2014) 6: 25-30 [PMID:25589925] |
| MAPK interacting serine/threonine kinase 2 in Human [GtoPdb: 2105] [UniProtKB: Q9HBH9] | ||||||||
| GtoPdb | Measured in a MIllipore kinase screening assay | - | 6.12 | pIC50 | 760 | nM | IC50 | ACS Med Chem Lett (2014) 6: 25-30 [PMID:25589925] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
