SKF-75670 [Ligand Id: 936] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1193571
  • D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
  • D1 receptor in Rat [GtoPdb: 214] [UniProtKB: P18901]
  • This target only has 1 pki data point
  • 8.7
1 CHEMBL1193571_lig_chart_1 Dopamine D1 receptor HumanRat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay B 5 pEC50 >10000 nM EC50 J Med Chem (2018) 61: 9841-9878 [PMID:29939744]
ChEMBL Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay B 9.35 pEC50 0.45 nM EC50 J Med Chem (2018) 61: 9841-9878 [PMID:29939744]
D1 receptor in Rat [GtoPdb: 214] [UniProtKB: P18901]
GtoPdb - - 8.7 pKi - - - Eur J Pharmacol (1990) 188: 335-47 [PMID:1973652]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]