asimadoline [Ligand Id: 9279] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1190199 (Asimadoline, EMD-61753) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| ChEMBL | Agonist activity at human delta opioid receptor expressed in COS7 cells after 60 mins IP1 assay | F | 5.1 | pEC50 | 8000 | nM | EC50 | Bioorg Med Chem Lett (2015) 25: 887-892 [PMID:25599839] |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| ChEMBL | Agonist activity at human kappa opioid receptor expressed in COS7 cells after 60 mins IP1 assay | F | 9.3 | pEC50 | 0.5 | nM | EC50 | Bioorg Med Chem Lett (2015) 25: 887-892 [PMID:25599839] |
| κ receptor in Guinea pig [GtoPdb: 318] | ||||||||
| GtoPdb | Displacement of [3H]- 69593 from K opioid receptors from guinea pig cerebellum. | - | 9 | pKi | 1 | nM | Ki | Bioorg Med Chem Lett (1994) 4: 677–682 |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| ChEMBL | Agonist activity at human mu opioid receptor expressed in COS7 cells after 60 mins IP1 assay | F | 4.22 | pEC50 | 60000 | nM | EC50 | Bioorg Med Chem Lett (2015) 25: 887-892 [PMID:25599839] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
