asimadoline [Ligand Id: 9279] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1190199 (Asimadoline, EMD-61753) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| ChEMBL | Agonist activity at human delta opioid receptor expressed in COS7 cells after 60 mins IP1 assay | F | 5.1 | pEC50 | 8000 | nM | EC50 | Bioorg Med Chem Lett (2015) 25: 887-892 [PMID:25599839] |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| ChEMBL | Agonist activity at human kappa opioid receptor expressed in COS7 cells after 60 mins IP1 assay | F | 9.3 | pEC50 | 0.5 | nM | EC50 | Bioorg Med Chem Lett (2015) 25: 887-892 [PMID:25599839] |
| κ receptor in Guinea pig [GtoPdb: 318] | ||||||||
| GtoPdb | Displacement of [3H]- 69593 from K opioid receptors from guinea pig cerebellum. | - | 9 | pKi | 1 | nM | Ki | Bioorg Med Chem Lett (1994) 4: 677–682 |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| ChEMBL | Agonist activity at human mu opioid receptor expressed in COS7 cells after 60 mins IP1 assay | F | 4.22 | pEC50 | 60000 | nM | EC50 | Bioorg Med Chem Lett (2015) 25: 887-892 [PMID:25599839] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
