upadacitinib [Ligand Id: 9246] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458] | ||||||||
| GtoPdb | - | - | 7.37 | pIC50 | 43 | nM | IC50 | WO2015061665. Jak1 selective inhibitor and uses thereof (2015) |
| GtoPdb | at 1uM ATP in a biochemical assay | - | 8.52 | pIC50 | 3 | nM | IC50 | WO2015061665. Jak1 selective inhibitor and uses thereof (2015) |
| Janus kinase 2 in Human [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
| GtoPdb | - | - | 6.92 | pIC50 | 120 | nM | IC50 | WO2015061665. Jak1 selective inhibitor and uses thereof (2015) |
| Janus kinase 3 in Human [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
| GtoPdb | - | - | 5.64 | pIC50 | 2300 | nM | IC50 | WO2015061665. Jak1 selective inhibitor and uses thereof (2015) |
| tyrosine kinase 2 in Human [GtoPdb: 2269] [UniProtKB: P29597] | ||||||||
| GtoPdb | - | - | 5.33 | pIC50 | 4700 | nM | IC50 | WO2015061665. Jak1 selective inhibitor and uses thereof (2015) |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
