periciazine [Ligand Id: 9216] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL251940 (Neulactil, NSC-758641, Periciazina, Periciazine, Pericyazine, Propericiazine, RP 8909, RP-8909, SKF 20716, SKF-20716)
Created with Highcharts 10.3.3ValuesChart context menuAcetylcholinesterasepKd BovinepKi BovinepIC50 BovinepEC50 Bovine0123456Highcharts.com
  • Androgen receptor/Androgen Receptor in Rat [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
Created with Highcharts 10.3.3ValuesChart context menuAndrogen ReceptorpKd RatpKi RatpIC50 RatpEC50 Rat0123456Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCholinesterasepKd Equus caballuspKi Equus caballuspIC50 Equus caballuspEC50 Equus caballus02468Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuPlasmodium falciparumpKd Plasmodium falciparumpKi Plasmodium falciparumpIC50 Plasmodium falciparumpEC50 Plasmodium falciparum0123456Highcharts.com
  • D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728]
Created with Highcharts 10.3.3ValuesChart context menuD1 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Acetylcholinesterase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4768] [UniProtKB: P23795]
ChEMBL Inhibition of bovine erythrocyte AChE using acetylthiocholine iodide as a substrate after 20 mins by Ellman's assay B 5.15 pIC50 7000 nM IC50 Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491]
Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
ChEMBL Displacement of [3H]mibolerone from rat androgen receptor B 5.52 pKi 3000 nM Ki Proc Natl Acad Sci U S A (2007) 104: 11927-11932 [PMID:17606915]
Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908]
ChEMBL Inhibition of Equine serum BChE using butyrylthiocholine iodide as a substrate after 20 mins by Ellman's assay B 6.64 pIC50 230 nM IC50 Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay F 5.18 pIC50 6562 nM IC50 Antimicrob Agents Chemother (2010) 54: 3597-3604 [PMID:20547797]
D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728]
GtoPdb - - 8 pKi 10 nM Ki J Psychiatry Neurosci (1994) 19: 265-9 [PMID:7918347]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]