C108297 [Ligand Id: 9180] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL270575
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
GtoPdb - - 9.15 pKi 0.7 nM Ki Bioorg Med Chem Lett (2008) 18: 1312-7 [PMID:18226897]
ChEMBL Displacement of [3H]dexamethasone from human recombinant GR B 9.15 pKi 0.7 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 1312-1317 [PMID:18226897]
ChEMBL Antagonist activity at GR in SW1353/MMTV5 cells assessed as inhibition of dexamethasone-induced luciferase expression F 9.22 pKi 0.6 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 1312-1317 [PMID:18226897]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]