[3H]JB-93182 [Ligand Id: 908] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL14557 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cholecystokinin A receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3501] [UniProtKB: Q63931] | ||||||||
| ChEMBL | Displacement of [125I]BH-CCK-8S from CC1 receptor expressed in guinea pig pancreatic cells | B | 5.4 | pKi | 3981.07 | nM | Ki | J Med Chem (2008) 51: 565-573 [PMID:18201065] |
| ChEMBL | In vitro inhibitory activity against Cholecystokinin type A receptor using [125I]BH-CCK-8S as radioligand in guinea pig pancreatic cells | B | 5.44 | pKi | 3630.78 | nM | Ki | J Med Chem (1996) 39: 1806-1815 [PMID:8627604] |
| CCK2 receptor/Cholecystokinin B receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2854] [GtoPdb: 77] [UniProtKB: P56481] | ||||||||
| ChEMBL | Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates | B | 8.95 | pKi | 1.12 | nM | Ki | J Med Chem (2000) 43: 3518-3529 [PMID:11000006] |
| ChEMBL | In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes | B | 8.96 | pKi | 1.1 | nM | Ki | J Med Chem (1996) 39: 1806-1815 [PMID:8627604] |
| CCK2 receptor/Cholecystokinin B receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553] | ||||||||
| GtoPdb | - | - | 9.5 | pKd | - | - | - | Br J Pharmacol (1999) 126: 1504-12 [PMID:10217546] |
| ChEMBL | Compound was tested for binding affinity against Cholecystokinin type B receptor in rat cortical membranes using L-365260 as the radioligand. | B | 7.63 | pKi | 23.44 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 1171-1174 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
