ChEMBL ligand: CHEMBL2047851 (PF-04859989)
Kynurenine/alpha-aminoadipate aminotransferase in Rat [ChEMBL: CHEMBL2662] [UniProtKB: Q64602] There should be some charts here, you may need to enable JavaScript!
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial in Human [ChEMBL: CHEMBL2046259] [UniProtKB: Q8N5Z0] There should be some charts here, you may need to enable JavaScript!
Kynurenine--oxoglutarate transaminase 3 in Human [ChEMBL: CHEMBL2046260] [UniProtKB: Q6YP21] There should be some charts here, you may need to enable JavaScript!
L-Cysteine:2-oxoglutarate aminotransferase/Kynurenine--oxoglutarate transaminase I in Human [ChEMBL: CHEMBL3962] [GtoPdb: 1445] [UniProtKB: Q16773] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Kynurenine/alpha-aminoadipate aminotransferase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2662] [UniProtKB: Q64602]
ChEMBL	Inhibition of rat recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrs	B	6.58	pIC50	263	nM	IC50	ACS Med Chem Lett (2012) 3: 187-192 [PMID:24900455]
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2046259] [UniProtKB: Q8N5Z0]
ChEMBL	Irreversible inhibition of human KAT2 using L-kynurenine as substrate measured every 5 mins over 16 hrs by SpectraMax plate reader analysis	B	7.85	pKi	14.2	nM	Ki	ACS Med Chem Lett (2013) 4: 37-40 [PMID:24900560]
ChEMBL	Inhibition of KAT2 (unknown origin)	B	7.85	pKi	14.2	nM	Ki	Medchemcomm (2013) 4: 125-129
ChEMBL	Inhibition of human KAT2 using L-kynurenine as substrate after 15 to 20 hrs by UV-visible spectra analysis	B	7.85	pKi	14	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1961-1966 [PMID:23466229]
ChEMBL	Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrs	B	7.64	pIC50	23	nM	IC50	ACS Med Chem Lett (2012) 3: 187-192 [PMID:24900455]
ChEMBL	Inhibition of human KAT2 using L-kynurenine as substrate measured after 15-20 hrs by SpectraMax plate reader analysis	B	7.64	pIC50	23	nM	IC50	ACS Med Chem Lett (2013) 4: 37-40 [PMID:24900560]
ChEMBL	Inhibition of KAT2 (unknown origin)	B	7.64	pIC50	23	nM	IC50	Medchemcomm (2013) 4: 125-129
ChEMBL	Inhibition of Kynurenine aminotransferase II (unknown origin)	B	7.64	pIC50	23	nM	IC50	Eur J Med Chem (2023) 251: 115258-115258 [PMID:36917881]
Kynurenine--oxoglutarate transaminase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2046260] [UniProtKB: Q6YP21]
ChEMBL	Inhibition of human KAT3	B	4.96	pIC50	11000	nM	IC50	ACS Med Chem Lett (2012) 3: 187-192 [PMID:24900455]
ChEMBL	Inhibition of human KAT3 using L-kynurenine as substrate measured after 24 hrs by SpectraMax plate reader analysis	B	5.04	pIC50	9040	nM	IC50	ACS Med Chem Lett (2013) 4: 37-40 [PMID:24900560]
L-Cysteine:2-oxoglutarate aminotransferase/Kynurenine--oxoglutarate transaminase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3962] [GtoPdb: 1445] [UniProtKB: Q16773]
ChEMBL	Inhibition of human KAT1 using L-kynurenine as substrate measured after 16 hrs by SpectraMax plate reader analysis	B	4.52	pIC50	30400	nM	IC50	ACS Med Chem Lett (2013) 4: 37-40 [PMID:24900560]
ChEMBL	Inhibition of human KAT1	B	4.66	pIC50	22000	nM	IC50	ACS Med Chem Lett (2012) 3: 187-192 [PMID:24900455]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]