ChEMBL ligand: CHEMBL3629569
indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902] There should be some charts here, you may need to enable JavaScript!
tryptophan 2,3-dioxygenase/Tryptophan 2,3-dioxygenase in Human [ChEMBL: CHEMBL2140] [GtoPdb: 2887] [UniProtKB: P48775] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902]
ChEMBL	Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis method	B	5.48	pKd	3300	nM	Kd	Eur J Med Chem (2017) 141: 169-177 [PMID:29031064]
ChEMBL	Inhibition of IDO1 (unknown origin) by in-vitro assay	B	8.14	pKi	7.2	nM	Ki	Eur J Med Chem (2017) 140: 293-304 [PMID:28963992]
ChEMBL	Inhibition of IDO1 (unknown origin)	B	8.15	pKi	7	nM	Ki	Medchemcomm (2017) 8: 1378-1392 [PMID:30108849]
GtoPdb	-	-	8.24	pKi	5.8	nM	Ki	J Med Chem (2019) 62: 6705-6733 [PMID:31264862]
ChEMBL	Inhibition of recombinant human IDO1 assessed as L-kynurenine release preincubated for 5 mins followed by addition of L-tryptophan for 15 mins by spectrophotometer	B	6	pIC50	<1000	nM	IC50	Medchemcomm (2016) 7: 409-419
ChEMBL	Inhibition of C-terminal 6His-tagged human IDO using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition measured after 15 mins by spectrophotometric analysis	B	6	pIC50	<1000	nM	IC50	J Med Chem (2015) 58: 9421-9437 [PMID:25970480]
ChEMBL	Inhibition of human IDO1	B	6	pIC50	<1000	nM	IC50	J Med Chem (2015) 58: 8762-8782 [PMID:26207924]
ChEMBL	Inhibition of full length recombinant human His-tagged IDO1 expressed in mouse LLTC cells using L-tryptophan as substrate after 24 hrs	B	6.23	pIC50	590	nM	IC50	Eur J Med Chem (2017) 126: 983-996 [PMID:28011425]
ChEMBL	Inhibition of IFNgamma-induced IDO1 in human HeLa cells using L-tryptophan as substrate after 24 hrs	B	6.39	pIC50	410	nM	IC50	Eur J Med Chem (2017) 138: 199-211 [PMID:28667875]
ChEMBL	Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 24 hrs	B	6.72	pIC50	190	nM	IC50	Eur J Med Chem (2019) 184: 111750-111750 [PMID:31610376]
ChEMBL	Inhibition of recombinant human IDO1 S167A mutant expressed in Escherichia coli SG13009(pREP4) using L-Tryptophan as substrate after 25 mins by fluorescence assay	B	6.89	pIC50	130	nM	IC50	Eur J Med Chem (2017) 126: 983-996 [PMID:28011425]
ChEMBL	Inhibition of recombinant human IDO1 expressed in Escherichia coli EC538 assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 30 mins by methylene blue reagent based concurrent assay	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem (2021) 39: 116160-116160 [PMID:33901770]
ChEMBL	Inhibition of recombinant human IDO1 expressed in Escherichia coli EC538 assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 30 mins by methylene blue reagent based assay	B	7.1	pIC50	80	nM	IC50	Bioorg Med Chem (2021) 39: 116160-116160 [PMID:33901770]
ChEMBL	Inhibition of purified human IDO1 using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins by spectrophotometric method	B	7.22	pIC50	60	nM	IC50	J Med Chem (2019) 62: 6705-6733 [PMID:31264862]
ChEMBL	Inhibition of recombinant human IDO1 expressed in bacterial expression system using L-Tryptophan as substrate after 25 mins in absence of GSH and presence of tween20 by fluorescence assay	B	7.22	pIC50	60	nM	IC50	Eur J Med Chem (2017) 126: 983-996 [PMID:28011425]
ChEMBL	Inhibition of recombinant human IDO1 assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 45 mins by methylene blue reagent based assay	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem (2021) 39: 116160-116160 [PMID:33901770]
ChEMBL	Inhibition of recombinant human IDO1 assessed as conversion of N-formylkynurenine to kynurenine incubated for 1 hr by fluorescence analysis	B	7.42	pIC50	38	nM	IC50	J Med Chem (2016) 59: 282-293 [PMID:26642377]
ChEMBL	Inhibition of IDO1 (unknown origin)	B	7.55	pIC50	28	nM	IC50	Medchemcomm (2016) 7: 409-419
ChEMBL	Inhibition of recombinant human IDO1 expressed in T-REx-293 cells assessed as reduction in kynurenine level measured after 16 hrs	B	7.08	pEC50	83	nM	EC50	J Med Chem (2019) 62: 6705-6733 [PMID:31264862]
ChEMBL	Inhibition of IDO1 (unknown origin) by cell based assay	B	7.12	pEC50	75	nM	EC50	Eur J Med Chem (2017) 140: 293-304 [PMID:28963992]
ChEMBL	Inhibition of IDO1 (unknown origin) by cell based assay	B	7.12	pEC50	75	nM	EC50	Medchemcomm (2017) 8: 1378-1392 [PMID:30108849]
ChEMBL	Inhibition of IDO1 in IFNgamma-stimulated human HeLa cells incubated for 24 hrs	B	7.21	pEC50	61	nM	EC50	J Med Chem (2016) 59: 282-293 [PMID:26642377]
tryptophan 2,3-dioxygenase/Tryptophan 2,3-dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2140] [GtoPdb: 2887] [UniProtKB: P48775]
GtoPdb	-	-	6	pIC50	<1000	nM	IC50	J Med Chem (2015) 58: 8762-82 [PMID:26207924]
ChEMBL	Inhibition of TDO (unknown origin)	B	6	pIC50	<1000	nM	IC50	J Med Chem (2015) 58: 8762-8782 [PMID:26207924]
ChEMBL	Inhibition of recombinant human TDO2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 30 mins by methylene blue reagent based concurrent assay	B	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2021) 39: 116160-116160 [PMID:33901770]
ChEMBL	Inhibition of recombinant human TDO2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 30 mins by methylene blue reagent based assay	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem (2021) 39: 116160-116160 [PMID:33901770]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]