LM10 [Ligand Id: 9016] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL1812545 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| tryptophan 2,3-dioxygenase in Human [GtoPdb: 2887] [UniProtKB: P48775] | ||||||||
| GtoPdb | - | - | 5.25 | pKi | 5600 | nM | Ki |
Proc Natl Acad Sci USA (2012) 109: 2497-502 [PMID:22308364]; J Med Chem (2011) 54: 5320-34 [PMID:21726069] |
| GtoPdb | Concentration inhibiting TDO activity by 50% in a cellular assay, at 80μM L-tryptophan. | - | 6.21 | pIC50 | 620 | nM | IC50 | Proc Natl Acad Sci USA (2012) 109: 2497-502 [PMID:22308364] |
| tryptophan 2,3-dioxygenase in Mouse [GtoPdb: 2887] [UniProtKB: P48776] | ||||||||
| GtoPdb | Concentration inhibiting TDO activity by 50% in a cellular assay, at 80μM L-tryptophan. | - | 5.71 | pIC50 | 1960 | nM | IC50 | Proc Natl Acad Sci USA (2012) 109: 2497-502 [PMID:22308364] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
