RB-400 [Ligand Id: 900] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL262197 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cholecystokinin A receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3501] [UniProtKB: Q63931] | ||||||||
| ChEMBL | Ability to displace 1 nM [3H]pCCK-8 from Cholecystokinin type A receptor in guinea pig pancreatic membranes | B | 9.12 | pKi | 0.75 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 369-372 [PMID:14698161] |
| ChEMBL | Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes. | B | 9.15 | pKi | >0.7 | nM | Ki | J Med Chem (2000) 43: 3614-3623 [PMID:11020275] |
| CCK2 receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239] | ||||||||
| ChEMBL | Binding affinity against cholecystokinin type B receptor on guinea pig cortex. | B | 9.55 | pKi | 0.28 | nM | Ki | J Med Chem (2000) 43: 3614-3623 [PMID:11020275] |
| CCK2 receptor/Cholecystokinin B receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553] | ||||||||
| ChEMBL | Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells | B | 5.52 | pKi | >3000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 369-372 [PMID:14698161] |
| GtoPdb | - | - | 9.1 | pKi | 0.79 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 369-72 [PMID:14698161] |
| ChEMBL | Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain. | B | 9.12 | pKi | 0.75 | nM | Ki | J Med Chem (2000) 43: 3614-3623 [PMID:11020275] |
| ChEMBL | Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain. | F | 9.4 | pEC50 | 0.4 | nM | EC50 | J Med Chem (2000) 43: 3614-3623 [PMID:11020275] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
