neostigmine [Ligand Id: 8993] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL278020 (Miostin, Neostigmine, Neostigmine (cation), Neostigmine cation, Neostigmine hydroxide, Neostigmine ion) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4780] [UniProtKB: P04058] | ||||||||
| ChEMBL | Inhibition of Torpedo californica eel AChE using acetylthiocholine/DTNB as substrate preincubated for 10 mins followed by substrate addition measured every 30 secs for 30 mins by Ellmans method | B | 8.34 | pIC50 | 4.6 | nM | IC50 | Medchemcomm (2011) 2: 406-412 |
| Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 4.55 | pIC50 | 28300 | nM | IC50 | Bioorg Med Chem (2014) 22: 6163-6173 [PMID:25257911] |
| ChEMBL | Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's method | B | 4.66 | pIC50 | 22000 | nM | IC50 | Eur J Med Chem (2014) 78: 43-53 [PMID:24675179] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured after 15 mins by Ellman's method | B | 4.79 | pIC50 | 16300 | nM | IC50 | Eur J Med Chem (2019) 180: 656-672 [PMID:31352246] |
| ChEMBL | Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's method | B | 4.85 | pIC50 | 14200 | nM | IC50 | Eur J Med Chem (2014) 78: 167-177 [PMID:24681981] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 5.12 | pIC50 | 7500 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127505-127505 [PMID:32822761] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
| ChEMBL | Inhibition of AChE (unknown origin) | B | 4.65 | pIC50 | 22200 | nM | IC50 | Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767] |
| ChEMBL | Inhibition of AChE (unknown origin) using ACh chloride as substrate preincubated for 15 mins before substrate addition by Ellman method | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3618-3621 [PMID:24909082] |
| GtoPdb | Inhibition of ACHE activity in human serum. | - | 7.35 | pIC50 | 45 | nM | IC50 | Bioorg Med Chem (2007) 15: 7391-8 [PMID:17888667] |
| butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
| ChEMBL | Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's method | B | 4.31 | pIC50 | 49100 | nM | IC50 | Eur J Med Chem (2014) 78: 43-53 [PMID:24675179] |
| ChEMBL | Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's method | B | 4.58 | pIC50 | 26100 | nM | IC50 | Eur J Med Chem (2014) 78: 167-177 [PMID:24681981] |
| ChEMBL | Inhibition of human BChE by Ellman's method | B | 4.79 | pIC50 | 16300 | nM | IC50 | Bioorg Med Chem (2014) 22: 6163-6173 [PMID:25257911] |
| Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908] | ||||||||
| ChEMBL | Inhibition of BuChE in equine serum using butyrylthiocholine chloride as substrate preincubated with enzyme for 10 mins prior to substrate challenge for 15 mins by Ellman's method | B | 4.3 | pIC50 | 49600 | nM | IC50 | Eur J Med Chem (2014) 78: 106-117 [PMID:24681070] |
| ChEMBL | Inhibition of equine BuChE by Ellman's method | B | 5.53 | pIC50 | 2930 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127505-127505 [PMID:32822761] |
| ChEMBL | Inhibition of equine BChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by DTNB reagent based Ellman's method | B | 6.8 | pIC50 | 160 | nM | IC50 | Bioorg Med Chem (2023) 78: 117132-117132 [PMID:36542960] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
