ChEMBL ligand: CHEMBL2337806
INPPL1/Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 in Human [ChEMBL: CHEMBL2331064] [GtoPdb: 1459] [UniProtKB: O15357] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
INPPL1/Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331064] [GtoPdb: 1459] [UniProtKB: O15357]
ChEMBL	Inhibition of human SHIP2 (419 to 732 residues) expressed in Escherichia coli by malachite green phosphate assay	B	6.36	pKi	440	nM	Ki	J Med Chem (2021) 64: 3813-3826 [PMID:33724834]
ChEMBL	Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as phosphate release using Ins(1,3,4,5)P4 as substrate incubated for 20 mins measured using microplate reader	B	5.82	pIC50	1500	nM	IC50	J Med Chem (2021) 64: 3813-3826 [PMID:33724834]
ChEMBL	Inhibition of SHIP2 (unknown origin)	B	6.21	pIC50	620	nM	IC50	Eur J Med Chem (2013) 62: 649-660 [PMID:23434638]
GtoPdb	IMeasured in a high-throughput screening assay.	-	6.21	pIC50	620	nM	IC50	Br J Pharmacol (2009) 158: 879-87 [PMID:19694723]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]