compound 4d [PMID: 20655626] [Ligand Id: 8852] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1253946
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  • CYP27A1/Sterol 26-hydroxylase, mitochondrial in Human [ChEMBL: CHEMBL5992] [GtoPdb: 1369] [UniProtKB: Q02318]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CYP24A1/Cytochrome P450 24A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4521] [GtoPdb: 1365] [UniProtKB: Q07973]
ChEMBL Inhibition of CYP24A1 expressed in CHO cells B 4.79 pIC50 16300 nM IC50 Eur J Med Chem (2010) 45: 4427-4434 [PMID:20655626]
GtoPdb - - 4.79 pIC50 16300 nM IC50 Eur J Med Chem (2010) 45: 4427-34 [PMID:20655626]
CYP27A1/Sterol 26-hydroxylase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5992] [GtoPdb: 1369] [UniProtKB: Q02318]
ChEMBL Inhibition of CYP27A1 expressed in CHO cells B 7.23 pIC50 59 nM IC50 Eur J Med Chem (2010) 45: 4427-4434 [PMID:20655626]
GtoPdb - - 7.23 pIC50 59 nM IC50 Eur J Med Chem (2010) 45: 4427-34 [PMID:20655626]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]