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ChEMBL ligand: CHEMBL1829872 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Dual specificity phosphatase 22 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3924] [UniProtKB: Q9NRW4] | ||||||||
ChEMBL | Inhibition of human GST-tagged full length MKPX assessed as DiFMUP hydrolysis by fluorometric kinetic-based assay | B | 5 | pIC50 | >10000 | nM | IC50 | Medchemcomm (2013) 4: 987-992 |
Papain in Carica papaya (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4779] [UniProtKB: P00784] | ||||||||
ChEMBL | Inhibition of papaya papain assessed as Z-Phe-Arg-pNA hydrolysis by fluorometric kinetic-based assay | B | 5 | pIC50 | >10000 | nM | IC50 | Medchemcomm (2013) 4: 987-992 |
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
ChEMBL | Competitive inhibition of human GST-tagged PTP1B catalytic domain assessed as rate of DiFMUP hydrolysis by lineweaver-burk plot analysis | B | 5.4 | pKi | 4000 | nM | Ki | Medchemcomm (2013) 4: 987-992 |
ChEMBL | Inhibition of human GST-tagged PTP1B catalytic domain assessed as DiFMUP hydrolysis by fluorometric kinetic-based assay | B | 5.31 | pIC50 | 4900 | nM | IC50 | Medchemcomm (2013) 4: 987-992 |
GtoPdb | - | - | 5.31 | pIC50 | 4900 | nM | IC50 | Medchemcomm (2013) : 987-992 |
RTP Type S/Receptor-type tyrosine-protein phosphatase S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396508] [GtoPdb: 1866] [UniProtKB: Q13332] | ||||||||
GtoPdb | - | - | 5.44 | pIC50 | 3600 | nM | IC50 | Medchemcomm (2013) : 987-992 |
ChEMBL | Inhibition of human GST-tagged PTP-sigma D1D2 domain assessed as DiFMUP hydrolysis by fluorometric kinetic-based assay | B | 5.44 | pIC50 | 3600 | nM | IC50 | Medchemcomm (2013) 4: 987-992 |
signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763] | ||||||||
ChEMBL | Inhibition of STAT3 using fluorescent probe 5-carboxyfluorescein-GpYLPQTV-NH2 after 15 mins by fluorescence polarisation assay | B | 4.88 | pKi | 13300 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 5605-5609 [PMID:21788134] |
signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5402] [GtoPdb: 2994] [UniProtKB: P42227] | ||||||||
ChEMBL | Inhibition of STAT3 in mouse NIH3T3/vSrc nuclear extract assessed as disruption of the Stat3-DNA complex pre-incubated for 30 mins by EMSA analysis | B | 4.54 | pIC50 | 28800 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 5605-5609 [PMID:21788134] |
protein tyrosine phosphatase non-receptor type 2/T-cell protein-tyrosine phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3807] [GtoPdb: 3255] [UniProtKB: P17706] | ||||||||
ChEMBL | Inhibition of human GST-tagged TC-PTP catalytic domain assessed as DiFMUP hydrolysis by fluorometric kinetic-based assay | B | 5.29 | pIC50 | 5100 | nM | IC50 | Medchemcomm (2013) 4: 987-992 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]