inhibitor A [PMID: 12482429] [Ligand Id: 8847] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL310981 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| sphingomyelin phosphodiesterase 2/Neutral sphingomyelinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4712] [GtoPdb: 2515] [UniProtKB: O60906] | ||||||||
| ChEMBL | Inhibitory activity against neutral sphingomyelinase (N-SMase) from bovine brain microsomes | B | 5.8 | pKi | 1600 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 229-236 [PMID:12482429] |
| ChEMBL | Inhibitory activity against neutral sphingomyelinase (N-SMase) from bovine brain microsomes | B | 5.48 | pIC50 | 3300 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 229-236 [PMID:12482429] |
| ChEMBL | Inhibitory activity against schyphostatin of neutral sphingomyelinase (N-SMase) from bovine brain microsome | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 229-236 [PMID:12482429] |
| sphingomyelin phosphodiesterase 2 in Bovine [GtoPdb: 2515] | ||||||||
| GtoPdb | - | - | 5.8 | pKi | 1600 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 229-36 [PMID:12482429] |
| sphingomyelin phosphodiesterase 1/Sphingomyelin phosphodiesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2760] [GtoPdb: 2514] [UniProtKB: P17405] | ||||||||
| ChEMBL | Inhibitory activity against Acid sphingomyelinase from bovine brain microsome | B | 4.31 | pIC50 | 49000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 229-236 [PMID:12482429] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
