7ACC2 [Ligand Id: 8818] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2442509 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Monocarboxylate transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4360] [GtoPdb: 988] [UniProtKB: P53985] | ||||||||
| ChEMBL | Inhibition of MCT1 in human SiHa cells by lactate reporter assay | B | 7.23 | pIC50 | 59 | nM | IC50 | Eur J Med Chem (2024) 267: 116170-116170 [PMID:38308950] |
| ChEMBL | Affinity On-target Cellular interaction: (Inhibition of [14C]lactate uptake in SiHa cells) EUB0002482a SLC16A1 | F | 7.23 | pIC50 | 59 | nM | IC50 | Affinity On-target Cellular Literature for EUbOPEN Chemogenomic Library |
| Monocarboxylate transporter 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073663] [GtoPdb: 989] [UniProtKB: O15427] | ||||||||
| ChEMBL | Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 24 hrs by liquid scintillation counting | B | 7.23 | pIC50 | 59 | nM | IC50 | Bioorg Med Chem (2013) 21: 7107-7117 [PMID:24095010] |
| ChEMBL | Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 12 mins by liquid scintillation counting | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem (2013) 21: 7107-7117 [PMID:24095010] |
| Monocarboxylate transporter 2 in Human [GtoPdb: 990] [UniProtKB: O60669] | ||||||||
| GtoPdb | - | - | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem (2013) 21: 7107-17 [PMID:24095010] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
