ChEMBL ligand: CHEMBL180650
5-lipoxygenase activating protein in Human [ChEMBL: CHEMBL4550] [UniProtKB: P20292] There should be some charts here, you may need to enable JavaScript!
mPGES1/Prostaglandin E synthase in Human [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684] There should be some charts here, you may need to enable JavaScript!
mPGES2/Prostaglandin E synthase 2 in Human [ChEMBL: CHEMBL4411] [GtoPdb: 1378] [UniProtKB: Q9H7Z7] There should be some charts here, you may need to enable JavaScript!
CYP5A1/Thromboxane-A synthase in Human [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-lipoxygenase activating protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4550] [UniProtKB: P20292]
ChEMBL	In vitro binding affinity against FLAP (5-Lipoxygenase activation protein)	B	6	pIC50	>1000	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3352-3355 [PMID:15953724]
ChEMBL	Inhibition of FLAP	B	6	pIC50	>1000	nM	IC50	J Med Chem (2008) 51: 4059-4067 [PMID:18459759]
mPGES1/Prostaglandin E synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684]
ChEMBL	Inhibition of purified mPGES-1 (1 to 152) (unknown origin) extracted from detergent-solubilized baculovirus-infected insect Sf9 cell membranes using PGH2 as substrate assessed as PGE2 production after 2.5 mins by LC/MS analysis	B	6.02	pIC50	960	nM	IC50	J Med Chem (2015) 58: 4727-4737 [PMID:25961169]
ChEMBL	Inhibition of recombinant human mPGES-1 expressed in human 293E cell microsomes using PGH2 as substrate assessed as PGE2 production after 2.5 mins by LC/MS analysis	B	7.64	pIC50	23	nM	IC50	J Med Chem (2015) 58: 4727-4737 [PMID:25961169]
GtoPdb	-	-	8.52	pIC50	3	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3352-5 [PMID:15953724]
ChEMBL	Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assay	B	8.52	pIC50	3	nM	IC50	J Med Chem (2011) 54: 3163-3174 [PMID:21466167]
mPGES2/Prostaglandin E synthase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4411] [GtoPdb: 1378] [UniProtKB: Q9H7Z7]
GtoPdb	-	-	6	pIC50	>1000	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3352-5 [PMID:15953724]
ChEMBL	In vitro inhibition against recombinant human mPGES-2	B	6	pIC50	>1000	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3352-3355 [PMID:15953724]
ChEMBL	Inhibition of human mPGES2	B	6	pIC50	>1000	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6816-6820 [PMID:18029174]
ChEMBL	Inhibition of mPGES2	B	6	pIC50	>1000	nM	IC50	J Med Chem (2008) 51: 4059-4067 [PMID:18459759]
ChEMBL	Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)	B	8.52	pIC50	3	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3352-3355 [PMID:15953724]
CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557]
ChEMBL	Inhibition of TX synthase	B	6	pIC50	>1000	nM	IC50	J Med Chem (2008) 51: 4059-4067 [PMID:18459759]
ChEMBL	In vitro inhibition against human Thromboxane synthase	B	6.02	pIC50	950	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3352-3355 [PMID:15953724]
ChEMBL	Inhibition of TX synthase	B	6.02	pIC50	950	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6816-6820 [PMID:18029174]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]