compound 51 [Crosignani et al., 2011] [Ligand Id: 8777] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2036213
  • DP2 receptor/G protein-coupled receptor 44 in Human [ChEMBL: CHEMBL5071] [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
Created with Highcharts 10.3.3ValuesChart context menuG protein-coupled receptor 44pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • CYP2C8 in Human [GtoPdb: 1325] [UniProtKB: P10632]
Created with Highcharts 10.3.3ValuesChart context menuCYP2C8pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • CYP2C9 in Human [GtoPdb: 1326] [UniProtKB: P11712]
Created with Highcharts 10.3.3ValuesChart context menuCYP2C9pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • CYP2C19 in Human [GtoPdb: 1328] [UniProtKB: P33261]
Created with Highcharts 10.3.3ValuesChart context menuCYP2C19pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DP2 receptor/G protein-coupled receptor 44 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5071] [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
GtoPdb - - 8.16 pKi 6.9 nM Ki ACS Med Chem Lett (2011) 2: 938-42 [PMID:24900284]
ChEMBL Displacement of [3HPGD2 from human CRTH2 receptor expressed in CHO cell membrane after 90 mins by scintillation proximity assay B 8.16 pKi 6.9 nM Ki ACS Med Chem Lett (2011) 2: 938-942 [PMID:24900284]
CYP2C8 in Human [GtoPdb: 1325] [UniProtKB: P10632]
GtoPdb - - 7.37 pIC50 43 nM IC50 ACS Med Chem Lett (2011) 2: 938-42 [PMID:24900284]
CYP2C9 in Human [GtoPdb: 1326] [UniProtKB: P11712]
GtoPdb - - 6.7 pIC50 200 nM IC50 ACS Med Chem Lett (2011) 2: 938-42 [PMID:24900284]
CYP2C19 in Human [GtoPdb: 1328] [UniProtKB: P33261]
GtoPdb - - 7.29 pIC50 51 nM IC50 ACS Med Chem Lett (2011) 2: 938-42 [PMID:24900284]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]