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ChEMBL ligand: CHEMBL2402205 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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kelch like ECH-associated protein 1/Kelch-like ECH-associated protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069156] [GtoPdb: 2757] [UniProtKB: Q14145] | ||||||||
GtoPdb | - | - | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem (2013) 21: 4011-9 [PMID:23647822] |
ChEMBL | Displacement of MR121-Nrf2 from human N-terminal His-tagged Kelch-DC domain of Keap1 (321 to 609) expressed in Escherichia coli BL21 (DE3) after 40 mins by 2D-FIDA assay | B | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem (2013) 21: 4011-4019 [PMID:23647822] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]