compound 21n [PMID: 17656086] [Ligand Id: 8750] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL235920 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| 15-LOX-1/Arachidonate 15-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050] | ||||||||
| ChEMBL | Competitive inhibition of human 15-LOX1 using linoleic acid as substrate after 10 mins by Lineweaver-Burk plot analysis | B | 7.14 | pKi | 73 | nM | Ki | J Med Chem (2015) 58: 7850-7862 [PMID:26331552] |
| ChEMBL | Competitive inhibition of human 15-LOX-1 assessed as reduction in conversion of linoleic acid to 13(S)-HpODE incubated for 10 mins followed by linoleic acid addition by Lineweaver-Burk plot analysis | B | 7.14 | pKi | 73 | nM | Ki | Eur J Med Chem (2016) 122: 786-801 [PMID:27477687] |
| Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530] | ||||||||
| ChEMBL | Inhibition of rabbit 15-lipoxygenase in presence of arachidonic acid | B | 7.12 | pIC50 | 75 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 5115-5120 [PMID:17656086] |
| ChEMBL | Inhibition of rabbit 15-lipoxygenase in presence of linoleic acid | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 5115-5120 [PMID:17656086] |
| 15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296] | ||||||||
| GtoPdb | - | - | 7.29 | pIC50 | 51 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 5115-20 [PMID:17656086] |
| ChEMBL | Inhibition of human recombinant 15-lipoxygenase over-expressed in CHO cells | B | 7.29 | pIC50 | 51 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 5115-5120 [PMID:17656086] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
