ChEMBL ligand: CHEMBL3040440 (PND-1186, SR-2516, Vs-4718, VS-4718)
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 10/Mitogen-activated protein kinase 10 in Human [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 9/Mitogen-activated protein kinase 9 in Human [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397]
GtoPdb	-	-	8.82	pIC50	1.5	nM	IC50	Cancer Biol Ther (2010) 9: 764-77 [PMID:20234191]
ChEMBL	Inhibition of GST-FAK catalytic domain region (411-686) (unknown origin) expressed in baculovirus infected Sf9 cells by spectrophotometry	B	8.82	pIC50	1.5	nM	IC50	ACS Med Chem Lett (2021) 12: 30-38 [PMID:33488961]
ChEMBL	Inhibition of GST-fused FAK (411 to 686 residues) (unknown origin) expressed in sf9 cells using poly(Glu:Tyr) (4:1) copolymer as substrate by spectrophotometric method	B	8.82	pIC50	1.5	nM	IC50	J Med Chem (2020) 63: 14382-14403 [PMID:33058670]
ChEMBL	Inhibition of GST-fused His-tagged recombinant FAK KD (411 to 686 residues) (unknown origin) expressed in baculovirus infected Sf9 cells using poly(Glu:Tyr) as substrate in presence of ATP by coomassie blue staining based ELISA screening assay	B	8.82	pIC50	1.5	nM	IC50	Cancer Biol Ther (2010) 9: 764-777 [PMID:20234191]
mitogen-activated protein kinase 10/Mitogen-activated protein kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
ChEMBL	Inhibition of JNK3 (unknown origin) using biotinylated ATF2 by HTRF method	B	6.8	pIC50	160	nM	IC50	Medchemcomm (2012) 3: 238-243
mitogen-activated protein kinase 9/Mitogen-activated protein kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
ChEMBL	Inhibition of JNK2 (unknown origin) using biotinylated ATF2 by HTRF method	B	6.92	pIC50	120	nM	IC50	Medchemcomm (2012) 3: 238-243

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]