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ChEMBL ligand: CHEMBL3040440 (PND-1186, SR-2516, Vs-4718, VS-4718) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984] | ||||||||
ChEMBL | Inhibition of JNK2 (unknown origin) using biotinylated ATF2 by HTRF method | B | 6.92 | pIC50 | 120 | nM | IC50 | Medchemcomm (2012) 3: 238-243 |
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] | ||||||||
ChEMBL | Inhibition of JNK3 (unknown origin) using biotinylated ATF2 by HTRF method | B | 6.8 | pIC50 | 160 | nM | IC50 | Medchemcomm (2012) 3: 238-243 |
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] | ||||||||
GtoPdb | - | - | 8.82 | pIC50 | 1.5 | nM | IC50 | Cancer Biol Ther (2010) 9: 764-77 [PMID:20234191] |
ChEMBL | Inhibition of GST-FAK catalytic domain region (411-686) (unknown origin) expressed in baculovirus infected Sf9 cells by spectrophotometry | B | 8.82 | pIC50 | 1.5 | nM | IC50 | ACS Med Chem Lett (2021) 12: 30-38 [PMID:33488961] |
ChEMBL | Inhibition of GST-fused FAK (411 to 686 residues) (unknown origin) expressed in sf9 cells using poly(Glu:Tyr) (4:1) copolymer as substrate by spectrophotometric method | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (2020) 63: 14382-14403 [PMID:33058670] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]