GSK2033 [Ligand Id: 8690] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1093266 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Liver X receptor-α/Oxysterols receptor LXR-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133] | ||||||||
| GtoPdb | - | - | 7 | pIC50 | - | - | - | J Med Chem (2010) 53: 3412-6 [PMID:20345102] |
| ChEMBL | Affinity On-target Cellular interaction: (Reporter gene assay (HEK293T cells)) EUB0000183b NR1H3 | F | 7 | pIC50 | 100 | nM | IC50 | Affinity On-target Cellular Literature for EUbOPEN Chemogenomic Library |
| Liver X receptor-β/Oxysterols receptor LXR-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055] | ||||||||
| ChEMBL | Affinity On-target Cellular interaction: (Reporter gene assay (HEK293T cells)) EUB0000183b NR1H2 | F | 7.4 | pIC50 | 40 | nM | IC50 | Affinity On-target Cellular Literature for EUbOPEN Chemogenomic Library |
| GtoPdb | - | - | 7.5 | pIC50 | - | - | - | J Med Chem (2010) 53: 3412-6 [PMID:20345102] |
| ChEMBL | Displacement of [N-methyl-3H]T1317 from human biotinylated LXRbeta LBD after 3 hrs by LEAD seeker binding assay | B | 7.5 | pIC50 | 31.62 | nM | IC50 | J Med Chem (2010) 53: 3412-3416 [PMID:20345102] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
