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ChEMBL ligand: CHEMBL2178579 (Elubrixin, Sb-656933, SB656933, SB-656933, SB-656933-AAF) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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CXCR1/Interleukin-8 receptor A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4029] [GtoPdb: 68] [UniProtKB: P25024] | ||||||||
ChEMBL | Binding affinity to CXCR1 | B | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2012) 55: 9363-9392 [PMID:22931505] |
CXCR2/Interleukin-8 receptor B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2434] [GtoPdb: 69] [UniProtKB: P25025] | ||||||||
ChEMBL | Antagonist activity at CXCR2 assessed as inhibition of neutrophil shape change | F | 6.51 | pIC50 | 310.5 | nM | IC50 | J. Med. Chem. (2012) 55: 9363-9392 [PMID:22931505] |
ChEMBL | Antagonist activity at CXCR2 assessed as inhibition of neutrophil CD11b up-regulation | F | 6.58 | pIC50 | 260.7 | nM | IC50 | J. Med. Chem. (2012) 55: 9363-9392 [PMID:22931505] |
GtoPdb | - | - | 7.66 | pIC50 | 22 | nM | IC50 | Pharmacol Rev (2014) 66: 1-79 [PMID:24218476] |
ChEMBL | Binding affinity to CXCR2 | B | 8.29 | pIC50 | 5.1 | nM | IC50 | J. Med. Chem. (2012) 55: 9363-9392 [PMID:22931505] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]