elubirixin [Ligand Id: 8499] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2178579 (Elubrixin, Elubrixina, Elubrixine, Sb-656933, SB-656933, SB656933, SB-656933-AAF) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CXCR1/Interleukin-8 receptor A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4029] [GtoPdb: 68] [UniProtKB: P25024] | ||||||||
| ChEMBL | Binding affinity to CXCR1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 9363-9392 [PMID:22931505] |
| CXCR2/Interleukin-8 receptor B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2434] [GtoPdb: 69] [UniProtKB: P25025] | ||||||||
| ChEMBL | Antagonist activity at CXCR2 assessed as inhibition of neutrophil shape change | F | 6.51 | pIC50 | 310.5 | nM | IC50 | J Med Chem (2012) 55: 9363-9392 [PMID:22931505] |
| ChEMBL | Antagonist activity at CXCR2 assessed as inhibition of neutrophil CD11b up-regulation | F | 6.58 | pIC50 | 260.7 | nM | IC50 | J Med Chem (2012) 55: 9363-9392 [PMID:22931505] |
| GtoPdb | - | - | 7.66 | pIC50 | 22 | nM | IC50 | Pharmacol Rev (2014) 66: 1-79 [PMID:24218476] |
| ChEMBL | Binding affinity to CXCR2 | B | 8.29 | pIC50 | 5.1 | nM | IC50 | J Med Chem (2012) 55: 9363-9392 [PMID:22931505] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
