LP-12 [Ligand Id: 8434] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL243954 |
|---|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Displacement of [3H]spiroperidol from human recombinant Dopamine D2 long receptor | B | 6.65 | pKi | 224 | nM | Ki | J Med Chem (2007) 50: 4214-4221 [PMID:17649988] |
| GtoPdb | - | - | 6.65 | pKi | 224 | nM | Ki | J Med Chem (2007) 50: 4214-21 [PMID:17649988] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cells | B | 7.22 | pKi | 60.9 | nM | Ki | J Med Chem (2007) 50: 4214-4221 [PMID:17649988] |
| GtoPdb | - | - | 7.22 | pKi | 60.9 | nM | Ki | J Med Chem (2007) 50: 4214-21 [PMID:17649988] |
| 5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| GtoPdb | - | - | 5.83 | pKi | 1464 | nM | Ki | J Med Chem (2007) 50: 4214-21 [PMID:17649988] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
| ChEMBL | Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley cortex membrane | B | 5.83 | pKi | 1464 | nM | Ki | J Med Chem (2007) 50: 4214-4221 [PMID:17649988] |
| 5-HT7 receptor in Human [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
| GtoPdb | - | - | 9.89 | pKi | 0.13 | nM | Ki | J Med Chem (2007) 50: 4214-21 [PMID:17649988] |
| 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305] | ||||||||
| ChEMBL | Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells | B | 9.89 | pKi | 0.13 | nM | Ki | J Med Chem (2007) 50: 4214-4221 [PMID:17649988] |
| Serotonin 7 (5-HT7) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5494] [UniProtKB: P50407] | ||||||||
| ChEMBL | Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction | F | 5.75 | pEC50 | 1770 | nM | EC50 | J Med Chem (2007) 50: 4214-4221 [PMID:17649988] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
