retosiban [Ligand Id: 8403] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL429736 (GSK-221149, GSK221149, GSK-221149A, GSK221149A, Retosiban) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| OT receptor/Oxytocin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2049] [GtoPdb: 369] [UniProtKB: P30559] | ||||||||
| ChEMBL | Binding affinity to recombinant oxytocin receptor | B | 8.39 | pKi | 4.1 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 90-94 [PMID:18032036] |
| ChEMBL | Binding affinity to human oxytocin receptor | B | 9 | pKi | 1 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 90-94 [PMID:18032036] |
| ChEMBL | Binding affinity to human oxytocin receptor | B | 9.19 | pKi | 0.65 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 90-94 [PMID:18032036] |
| GtoPdb | - | - | 9.19 | pKi | 0.65 | nM | Ki |
Am J Physiol Regul Integr Comp Physiol (2007) 293: R299-305 [PMID:17395790]; Bioorg Med Chem Lett (2008) 18: 90-4 [PMID:18032036] |
| ChEMBL | Displacement of [3H]-oxytocin from oxytocin receptor in human uterus tissue | B | 9.2 | pKi | 0.63 | nM | Ki | J Med Chem (2010) 53: 6525-6538 [PMID:20550119] |
| V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288] | ||||||||
| ChEMBL | Binding affinity to human vasopressin V1a receptor | B | 4.92 | pKi | >12000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 90-94 [PMID:18032036] |
| V1B receptor/Vasopressin V1b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1921] [GtoPdb: 367] [UniProtKB: P47901] | ||||||||
| ChEMBL | Binding affinity to human vasopressin V1b receptor | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 90-94 [PMID:18032036] |
| V2 receptor/Vasopressin V2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518] | ||||||||
| ChEMBL | Binding affinity to human vasopressin V2 receptor | B | 6.02 | pKi | 950 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 90-94 [PMID:18032036] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
