TAK-441 [Ligand Id: 8200] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2205230 (Tak-441)
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  • SMO in Mouse [GtoPdb: 239] [UniProtKB: P56726]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Sonic hedgehog protein in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5387] [UniProtKB: Q62226]
ChEMBL Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter gene assay B 8.36 pIC50 4.4 nM IC50 Bioorg Med Chem (2012) 20: 5507-5517 [PMID:22898254]
SMO in Mouse [GtoPdb: 239] [UniProtKB: P56726]
GtoPdb - - 8.36 pIC50 4.4 nM IC50 Bioorg Med Chem (2012) 20: 5507-17 [PMID:22898254]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]