ChEMBL ligand: CHEMBL2105737 (Erismodegib, LDE 225, LDE-225, LDE225, NVP-LDE 225, NVP-LDE-225, NVP-LDE225, Sonidegib)
SMO/Smoothened homolog in Human [ChEMBL: CHEMBL5971] [GtoPdb: 239] [UniProtKB: Q99835] There should be some charts here, you may need to enable JavaScript!
Sonic hedgehog protein in Mouse [ChEMBL: CHEMBL5387] [UniProtKB: Q62226] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
SMO/Smoothened homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5971] [GtoPdb: 239] [UniProtKB: Q99835]
GtoPdb	-	-	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2012) 20: 6751-7 [PMID:23063522]
ChEMBL	Displacement of [3H]cyclopamine from wild type Smo expressed in U2OS cells after 2 hrs by scintillation counting	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2012) 20: 6751-6757 [PMID:23063522]
Sonic hedgehog protein in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5387] [UniProtKB: Q62226]
ChEMBL	Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assay	B	8.26	pIC50	5.5	nM	IC50	Bioorg Med Chem Lett (2013) 23: 6777-6783 [PMID:24176396]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]