compound 17d [PMID: 23099093] [Ligand Id: 8196] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2207198
  • BR serine/threonine kinase 2/BR serine/threonine-protein kinase 2 in Human [ChEMBL: CHEMBL4574] [GtoPdb: 1947] [UniProtKB: Q8IWQ3]
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  • cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
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  • inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164]
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  • MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5]
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  • aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
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  • microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448]
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  • TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2]
  • TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Mouse [ChEMBL: CHEMBL2189160] [GtoPdb: 2237] [UniProtKB: Q9WUN2]
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  • mitogen-activated protein kinase kinase kinase 7 in Human [GtoPdb: 2082] [UniProtKB: O43318]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
BR serine/threonine kinase 2/BR serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4574] [GtoPdb: 1947] [UniProtKB: Q8IWQ3]
ChEMBL Inhibition of BRSK2 B 5.72 pIC50 1900 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 7169-7173 [PMID:23099093]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL Inhibition of CDK2 B 6.2 pIC50 630 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 7169-7173 [PMID:23099093]
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164]
GtoPdb - - 7.52 pIC50 30 nM IC50 Bioorg Med Chem Lett (2012) 22: 7169-73 [PMID:23099093]
ChEMBL Inhibition of IKKepsilon B 7.52 pIC50 30 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 7169-7173 [PMID:23099093]
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5]
ChEMBL Inhibition of MNK1 B 4.72 pIC50 19000 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 7169-7173 [PMID:23099093]
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
ChEMBL Inhibition of Aurora B B 6.15 pIC50 700 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 7169-7173 [PMID:23099093]
microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448]
GtoPdb - - 7.92 pIC50 12 nM IC50 Bioorg Med Chem Lett (2012) 22: 7169-73 [PMID:23099093]
ChEMBL Inhibition of MARK3 B 7.92 pIC50 12 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 7169-7173 [PMID:23099093]
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2]
GtoPdb - - 8.22 pIC50 6 nM IC50 Bioorg Med Chem Lett (2012) 22: 7169-73 [PMID:23099093]
ChEMBL Inhibition of TBK1 by radiometry B 8.22 pIC50 6 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 7169-7173 [PMID:23099093]
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189160] [GtoPdb: 2237] [UniProtKB: Q9WUN2]
ChEMBL Inhibition of TBK1-mediated RANTES release in LPS-stimulated mouse RAW264.7 cells compound incubated for 30 mins prior LPS challenge measured after 6 hrs by ELISA B 7.24 pIC50 58 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 7169-7173 [PMID:23099093]
mitogen-activated protein kinase kinase kinase 7 in Human [GtoPdb: 2082] [UniProtKB: O43318]
GtoPdb - - 7.92 pIC50 12 nM IC50 Bioorg Med Chem Lett (2012) 22: 7169-73 [PMID:23099093]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]