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ChEMBL ligand: CHEMBL2207198 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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BR serine/threonine kinase 2/BR serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4574] [GtoPdb: 1947] [UniProtKB: Q8IWQ3] | ||||||||
ChEMBL | Inhibition of BRSK2 | B | 5.72 | pIC50 | 1900 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7169-7173 [PMID:23099093] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibition of CDK2 | B | 6.2 | pIC50 | 630 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7169-7173 [PMID:23099093] |
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164] | ||||||||
GtoPdb | - | - | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7169-73 [PMID:23099093] |
ChEMBL | Inhibition of IKKepsilon | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7169-7173 [PMID:23099093] |
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5] | ||||||||
ChEMBL | Inhibition of MNK1 | B | 4.72 | pIC50 | 19000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7169-7173 [PMID:23099093] |
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] | ||||||||
ChEMBL | Inhibition of Aurora B | B | 6.15 | pIC50 | 700 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7169-7173 [PMID:23099093] |
microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448] | ||||||||
GtoPdb | - | - | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7169-73 [PMID:23099093] |
ChEMBL | Inhibition of MARK3 | B | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7169-7173 [PMID:23099093] |
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2] | ||||||||
GtoPdb | - | - | 8.22 | pIC50 | 6 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7169-73 [PMID:23099093] |
ChEMBL | Inhibition of TBK1 by radiometry | B | 8.22 | pIC50 | 6 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7169-7173 [PMID:23099093] |
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189160] [GtoPdb: 2237] [UniProtKB: Q9WUN2] | ||||||||
ChEMBL | Inhibition of TBK1-mediated RANTES release in LPS-stimulated mouse RAW264.7 cells compound incubated for 30 mins prior LPS challenge measured after 6 hrs by ELISA | B | 7.24 | pIC50 | 58 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7169-7173 [PMID:23099093] |
mitogen-activated protein kinase kinase kinase 7 in Human [GtoPdb: 2082] [UniProtKB: O43318] | ||||||||
GtoPdb | - | - | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7169-73 [PMID:23099093] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]