ChEMBL ligand: CHEMBL2069623
casein kinase 1 alpha 1/Casein kinase I isoform alpha in Human [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729] There should be some charts here, you may need to enable JavaScript!
casein kinase 1 delta/Casein kinase I isoform delta in Human [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730] There should be some charts here, you may need to enable JavaScript!
casein kinase 1 epsilon/Casein kinase I isoform epsilon in Human [ChEMBL: CHEMBL4937] [GtoPdb: 1998] [UniProtKB: P49674] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
casein kinase 1 alpha 1/Casein kinase I isoform alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729]
ChEMBL	Identification of CSNK1A1 Inhibitors: In order to identify inhibitors of CSNK1A1, the CSNK1A1 knockdown signatures in CMap were compared to all CMap compound signatures, and resultant compounds were ranked by strength of signature similarity. The top ranked compound from this analysis (compound 1) was predicted to act as a CSNK1A1 inhibitor.The CMap prediction was confirmed using Kinomescan (FIG. 1 ). Compound 1 bound to only six out of over 400 kinases tested in the assay, including CSNK1A1.	B	6.07	pIC50	857	nM	IC50	US-11633415-B2. Compounds and methods useful for treating or preventing cancers (2023)
casein kinase 1 delta/Casein kinase I isoform delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730]
ChEMBL	Inhibition of CK1delta	B	6.15	pIC50	711	nM	IC50	Eur J Med Chem (2012) 56: 30-38 [PMID:22944772]
ChEMBL	Inhibition of Casein kinase 1 delta	B	6.15	pIC50	711	nM	IC50	J Med Chem (2012) 55: 10307-10311 [PMID:23106386]
ChEMBL	Inhibition of human CK1delta in presence of [gamma33P]-ATP	B	6.15	pIC50	711	nM	IC50	Eur J Med Chem (2019) 181: 111581-111581 [PMID:31400711]
ChEMBL	Inhibition of CK1delta (unknown origin)	B	6.15	pIC50	711	nM	IC50	J Med Chem (2023) 66: 7162-7178 [PMID:37204207]
GtoPdb	-	-	6.15	pIC50	711	nM	IC50	J Pharmacol Exp Ther (2009) 330: 430-9 [PMID:19458106]
ChEMBL	Inhibition of human full length CK1delta1 (2 to 415 residues) using PLSRTLpSVASLPGL as substrate after 2 hrs by kinase-glo assay	B	7.49	pIC50	32	nM	IC50	Nat Rev Drug Discov (2017) 16: 424-440 [PMID:28280261]
casein kinase 1 epsilon/Casein kinase I isoform epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4937] [GtoPdb: 1998] [UniProtKB: P49674]
GtoPdb	-	-	7.49	pIC50	32	nM	IC50	J Pharmacol Exp Ther (2009) 330: 430-9 [PMID:19458106]
ChEMBL	Inhibition of CK1epsilon	B	7.49	pIC50	32	nM	IC50	Eur J Med Chem (2012) 56: 30-38 [PMID:22944772]
ChEMBL	Inhibition of Casein kinase 1 epsilon	B	7.49	pIC50	32	nM	IC50	J Med Chem (2012) 55: 10307-10311 [PMID:23106386]
ChEMBL	Inhibition of human full length polyhistidine-tagged CK1epsilon expressed in Escherichia coli BL21-Codon-Plus (DE3)-RIL using PLSRTLpSVASLPGL as substrate after 2 hrs by kinase-glo assay	B	7.49	pIC50	32	nM	IC50	Nat Rev Drug Discov (2017) 16: 424-440 [PMID:28280261]
ChEMBL	Inhibition of human CK1epsilon in presence of [gamma33P]-ATP	B	7.49	pIC50	32	nM	IC50	Eur J Med Chem (2019) 181: 111581-111581 [PMID:31400711]
ChEMBL	Inhibition of CK1epsilon (unknown origin)	B	7.49	pIC50	32	nM	IC50	J Med Chem (2023) 66: 7162-7178 [PMID:37204207]
ChEMBL	Inhibition of recombinant human full-length N-terminal GST-tagged CK1epsilon expressed in baculovirus infected Sf9 insect cells using casein as substrate measured after 60 mins by ADP-glo kinase assay	B	8.13	pEC50	7.4	nM	EC50	Blood (2017) 129: 88-99 [PMID:27784673]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]