ancriviroc [Ligand Id: 804] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL78535 (Ancriviroc, SCH351125, SCH-351125)
  • CCR5/C-C chemokine receptor type 5 in Human [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681]
  • CCR5/C-C chemokine receptor type 5 in Mouse [ChEMBL: CHEMBL3676] [GtoPdb: 62] [UniProtKB: P51682]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CCR5/C-C chemokine receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681]
ChEMBL Inhibition of RANTES binding to C-C chemokine receptor type 5 B 8.68 pKi 2.1 nM Ki J Med Chem (2001) 44: 3339-3342 [PMID:11585437]
ChEMBL Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5) B 8.68 pKi 2.1 nM Ki J Med Chem (2003) 46: 4501-4515 [PMID:14521412]
GtoPdb - - 8.7 pKi - - - J Biol Chem (2006) 281: 12688-12698 [PMID:16476734];
Antimicrob Agents Chemother (2005) 49: 4911-9 [PMID:16304152];
J Med Chem (2001) 44: 3339-42 [PMID:11585437]
CCR5/C-C chemokine receptor type 5 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3676] [GtoPdb: 62] [UniProtKB: P51682]
ChEMBL Inhibition of RANTES binding to Chemokine receptor type 5 receptor from NIH 3T3 cells B 8.68 pKi 2.1 nM Ki J Med Chem (2002) 45: 3143-3160 [PMID:12086500]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]