Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL24773 |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta | B | 4.15 | pIC50 | 70000 | nM | IC50 | J Med Chem (2002) 45: 1292-1299 [PMID:11881998] |
ChEMBL | Inhibition of GSK3beta | B | 4.15 | pIC50 | 70000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 146-150 [PMID:22368763] |
regulator of G-protein signaling 4/Regulator of G-protein signaling 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795091] [GtoPdb: 2811] [UniProtKB: P49798] | ||||||||
GtoPdb | Inhibition of Gαo binding | - | 7.84 | pIC50 | 14.4 | nM | IC50 | ACS Med Chem Lett (2012) 3: 146-150 [PMID:22368763] |
ChEMBL | Inhibition of RGS4 interaction with Galpha0 protein by flow cytometry protein interaction assay | B | 7.84 | pIC50 | 14.4 | nM | IC50 | ACS Med Chem Lett (2012) 3: 146-150 [PMID:22368763] |
regulator of G-protein signaling 8/Regulator of G-protein signaling 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034803] [GtoPdb: 2813] [UniProtKB: P57771] | ||||||||
ChEMBL | Inhibition of RGS8 interaction with Galpha0 protein by flow cytometry protein interaction assay | B | 4.08 | pIC50 | 83500 | nM | IC50 | ACS Med Chem Lett (2012) 3: 146-150 [PMID:22368763] |
GtoPdb | Inhibition of Gαo binding | - | 4.08 | pIC50 | 83500 | nM | IC50 | ACS Med Chem Lett (2012) 3: 146-150 [PMID:22368763] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]