ChEMBL ligand: CHEMBL351706 (Bms 214662, Bms-214662, BMS-214662)
farnesyltransferase, CAAX box, subunit alpha/Geranylgeranyl transferase type I in Human [ChEMBL: CHEMBL2095164] [GtoPdb: 2825] [UniProtKB: P49354, P53609]
KRAS/GTPase KRas in Human [ChEMBL: CHEMBL2189121] [GtoPdb: 2824] [UniProtKB: P01116]
farnesyltransferase, CAAX box, subunit alpha/farnesyltransferase, CAAX box, subunit beta/Protein farnesyltransferase in Human [ChEMBL: CHEMBL2094108] [GtoPdb: 2825, 2826] [UniProtKB: P49354, P49356]
HRAS/Transforming protein p21/H-Ras-1 in Human [ChEMBL: CHEMBL2167] [GtoPdb: 2822] [UniProtKB: P01112]

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
farnesyltransferase, CAAX box, subunit alpha/Geranylgeranyl transferase type I in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095164] [GtoPdb: 2825] [UniProtKB: P49354, P53609]
ChEMBL	Inhibition of geranylgeranyl transferase (GGT1) using K-Ras as substrate	B	5.64	pIC50	2300	nM	IC50	J Med Chem (2000) 43: 3587-3595 [PMID:11020273]
ChEMBL	Inhibition of geranylgeranyl transferase (GGT1) using Ras-CVLL as substrate	B	5.89	pIC50	1300	nM	IC50	J Med Chem (2000) 43: 3587-3595 [PMID:11020273]
KRAS/GTPase KRas in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189121] [GtoPdb: 2824] [UniProtKB: P01116]
ChEMBL	Inhibition of K-Ras (unknown origin) geranylgeranylation	B	5.64	pIC50	2300	nM	IC50	Eur J Med Chem (2021) 211: 113006-113006 [PMID:33228976]
ChEMBL	Inhibition of K-Ras (unknown origin) farnesylation	B	8.08	pIC50	8.4	nM	IC50	Eur J Med Chem (2021) 211: 113006-113006 [PMID:33228976]
ChEMBL	Inhibition of human K-ras	B	8.08	pIC50	8.4	nM	IC50	Eur J Med Chem (2021) 226: 113877-113877 [PMID:34624823]
farnesyltransferase, CAAX box, subunit alpha/farnesyltransferase, CAAX box, subunit beta/Protein farnesyltransferase in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094108] [GtoPdb: 2825, 2826] [UniProtKB: P49354, P49356]
ChEMBL	Inhibition of farnesyltransferase (unknown origin) assessed as KRAS farnesylation	B	8.08	pIC50	8.4	nM	IC50	J Med Chem (2013) 56: 5219-5230 [PMID:23566315]
ChEMBL	Inhibitory concentration against farnesyltransferase was determined	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2004) 47: 1869-1878 [PMID:15055985]
ChEMBL	Inhibition of human FTase	B	8.85	pIC50	1.4	nM	IC50	Bioorg Med Chem Lett (2012) 22: 6896-6902 [PMID:23036952]
ChEMBL	Inhibition of human recombinant FTase	B	8.87	pIC50	1.35	nM	IC50	J Med Chem (2018) 61: 3239-3252 [PMID:28505447]
ChEMBL	Inhibition of purified recombinant human farnesyltransferase (FT)	B	8.87	pIC50	1.35	nM	IC50	J Med Chem (2000) 43: 3587-3595 [PMID:11020273]
GtoPdb	-	-	8.87	pIC50	1.35	nM	IC50	J Med Chem (2000) 43: 3587-95 [PMID:11020273]
ChEMBL	Inhibition of farnesyltransferase	B	8.89	pIC50	1.3	nM	IC50	Bioorg Med Chem Lett (2004) 14: 767-771 [PMID:14741286]
ChEMBL	Inhibition of farnesyltransferase (unknown origin) assessed as HRAS farnesylation	B	8.89	pIC50	1.3	nM	IC50	J Med Chem (2013) 56: 5219-5230 [PMID:23566315]
ChEMBL	Inhibition of Farnesyltransferase	B	9.15	pIC50	0.7	nM	IC50	J Med Chem (2004) 47: 612-626 [PMID:14736242]
HRAS/Transforming protein p21/H-Ras-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2167] [GtoPdb: 2822] [UniProtKB: P01112]
ChEMBL	Inhibition of HRAS (unknown origin) farnesylation	B	8.89	pIC50	1.3	nM	IC50	Eur J Med Chem (2021) 211: 113006-113006 [PMID:33228976]
ChEMBL	Inhibition of human H-ras	B	8.89	pIC50	1.3	nM	IC50	Eur J Med Chem (2021) 226: 113877-113877 [PMID:34624823]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]