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ChEMBL ligand: CHEMBL2107823 (Gandotinib, Ly-2784544, Ly2784544, LY-2784544, LY2784544) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
ChEMBL | Further kinetic evaluation of compounds supplied by Sanofi against AuroraA within a BIAcore3000 instrument | B | 7.82 | pKd | 15.05 | nM | Kd | K4DD drug target binding kinetics data |
Janus kinase 2 in Human [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
GtoPdb | - | - | 8.4 | pIC50 | 4 | nM | IC50 | Blood Cancer J (2013) 3: e109 [PMID:23584399] |
Janus kinase 3 in Human [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
GtoPdb | - | - | 7.32 | pIC50 | 48 | nM | IC50 | Blood Cancer J (2013) 3: e109 [PMID:23584399] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]