ChEMBL ligand: CHEMBL1236539 (7-Hydroxystaurosporine)
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] There should be some charts here, you may need to enable JavaScript!
protein kinase C alpha in Human [GtoPdb: 1482] [UniProtKB: P17252] There should be some charts here, you may need to enable JavaScript!
protein kinase C beta in Human [GtoPdb: 1483] [UniProtKB: P05771] There should be some charts here, you may need to enable JavaScript!
protein kinase C gamma in Human [GtoPdb: 1484] [UniProtKB: P05129] There should be some charts here, you may need to enable JavaScript!
protein kinase C delta in Human [GtoPdb: 1485] [UniProtKB: Q05655] There should be some charts here, you may need to enable JavaScript!
protein kinase C epsilon in Human [GtoPdb: 1486] [UniProtKB: Q02156] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 14 in Human [GtoPdb: 1499] [UniProtKB: Q16539] There should be some charts here, you may need to enable JavaScript!
3-phosphoinositide dependent protein kinase 1 in Human [GtoPdb: 1519] [UniProtKB: O15530] There should be some charts here, you may need to enable JavaScript!
protein kinase A in Rat [GtoPdb: 1694] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493] There should be some charts here, you may need to enable JavaScript!
checkpoint kinase 2 in Human [GtoPdb: 1988] [UniProtKB: O96017] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 beta in Human [GtoPdb: 2030] [UniProtKB: P49841] There should be some charts here, you may need to enable JavaScript!
LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239] There should be some charts here, you may need to enable JavaScript!
microtubule affinity regulating kinase 1 in Human [GtoPdb: 2097] [UniProtKB: Q9P0L2] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
ChEMBL	Inhibition of CHK1 (unknown origin) using FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide substrate incubated for 1 hr by caliper microfluidic assay	B	8.01	pIC50	9.88	nM	IC50	Eur J Med Chem (2015) 92: 459-470 [PMID:25594740]
GtoPdb	-	-	8.15	pIC50	7	nM	IC50	Mol Cancer Ther (2004) 3: 1221-7 [PMID:15486189]; Cancer Cell (2007) 11: 175-89 [PMID:17292828]; Cancer Res (2000) 60: 2108-12 [PMID:10786669]
protein kinase C alpha in Human [GtoPdb: 1482] [UniProtKB: P17252]
GtoPdb	-	-	7.54	pIC50	29	nM	IC50	Mol Pharmacol (1994) 45: 1207-14 [PMID:8022414]
protein kinase C beta in Human [GtoPdb: 1483] [UniProtKB: P05771]
GtoPdb	-	-	7.54	pIC50	34	nM	IC50	Mol Pharmacol (1994) 45: 1207-14 [PMID:8022414]
protein kinase C gamma in Human [GtoPdb: 1484] [UniProtKB: P05129]
GtoPdb	-	-	7.52	pIC50	30	nM	IC50	Mol Pharmacol (1994) 45: 1207-14 [PMID:8022414]
protein kinase C delta in Human [GtoPdb: 1485] [UniProtKB: Q05655]
GtoPdb	-	-	6.23	pIC50	590	nM	IC50	Mol Pharmacol (1994) 45: 1207-14 [PMID:8022414]
protein kinase C epsilon in Human [GtoPdb: 1486] [UniProtKB: Q02156]
GtoPdb	-	-	6.28	pIC50	530	nM	IC50	Mol Pharmacol (1994) 45: 1207-14 [PMID:8022414]
mitogen-activated protein kinase 14 in Human [GtoPdb: 1499] [UniProtKB: Q16539]
GtoPdb	-	-	7.02	pIC50	95	nM	IC50	Cancer Cell (2007) 11: 175-89 [PMID:17292828]
3-phosphoinositide dependent protein kinase 1 in Human [GtoPdb: 1519] [UniProtKB: O15530]
GtoPdb	-	-	7.48	pIC50	33	nM	IC50	Oncogene (2002) 21: 1727-38 [PMID:11896604]
protein kinase A in Rat [GtoPdb: 1694]
GtoPdb	-	-	6	pIC50	1000	nM	IC50	Mol Cancer Ther (2004) 3: 1221-7 [PMID:15486189]
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
GtoPdb	-	-	7.3	pIC50	50	nM	IC50	Mol Cancer Ther (2004) 3: 1221-7 [PMID:15486189]
checkpoint kinase 2 in Human [GtoPdb: 1988] [UniProtKB: O96017]
GtoPdb	-	-	5.98	pIC50	1040	nM	IC50	Cancer Res (2000) 60: 2108-12 [PMID:10786669]
glycogen synthase kinase 3 beta in Human [GtoPdb: 2030] [UniProtKB: P49841]
GtoPdb	-	-	6.3	pIC50	500	nM	IC50	Mol Cancer Ther (2004) 3: 1221-7 [PMID:15486189]
LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239]
GtoPdb	-	-	7.3	pIC50	50	nM	IC50	Mol Cancer Ther (2004) 3: 1221-7 [PMID:15486189]
microtubule affinity regulating kinase 1 in Human [GtoPdb: 2097] [UniProtKB: Q9P0L2]
GtoPdb	-	-	7.57	pIC50	27	nM	IC50	Cancer Res (2000) 60: 2108-12 [PMID:10786669]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]