ChEMBL ligand: CHEMBL2347211
beta-secretase 1/Beta-secretase 1 in Human [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817] There should be some charts here, you may need to enable JavaScript!
beta-secretase 2/Beta secretase 2 in Human [ChEMBL: CHEMBL2525] [GtoPdb: 2331] [UniProtKB: Q9Y5Z0] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
GtoPdb	-	-	7.74	pIC50	18	nM	IC50	Cell Metab (2011) 14: 365-77 [PMID:21907142]
ChEMBL	Inhibition of recombinant human BACE1 using biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 3 hrs by fluorescence assay	B	7.74	pIC50	18	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2033-2045 [PMID:24704031]
ChEMBL	Inhibition of human BACE1 using MR121-labeled substrate incubated for 4 mins prior to substrate addition measured after 2 mins by spectrophotometric analysis	B	7.8	pIC50	16	nM	IC50	J Med Chem (2013) 56: 3980-3995 [PMID:23590342]
ChEMBL	Inhibition of BACE1 (unknown origin)	B	8.17	pIC50	6.7	nM	IC50	J Med Chem (2018) 61: 5122-5137 [PMID:29733614]
ChEMBL	Inhibition of BACE1 (1 to 454 residues) (unknown origin) using Mca-APP Swedish Lys-Met/Asn-Leu mutant-Dnp quencher as substrate by fluorescence assay	B	8.34	pIC50	4.6	nM	IC50	J Med Chem (2019) 62: 5080-5095 [PMID:31021626]
ChEMBL	Inhibition of human BACE1 in HEK293 cells transfected with wild type APP assessed as reduction of amyloid beta40 level after 18 to 20 hrs by AlphaLISA technique	B	9	pIC50	1	nM	IC50	J Med Chem (2013) 56: 3980-3995 [PMID:23590342]
ChEMBL	Inhibition of BACE1 in human SKNBE2 cells expressing APP695 assessed as reduction in Abeta42 level measured after 18 hrs by sandwich ELISA	B	9.03	pIC50	0.93	nM	IC50	J Med Chem (2019) 62: 5080-5095 [PMID:31021626]
ChEMBL	Inhibition of BACE1 (unknown origin) assessed as reduction in amyloid beta production by cell based assay	B	9.08	pIC50	0.84	nM	IC50	J Med Chem (2018) 61: 5122-5137 [PMID:29733614]
beta-secretase 2/Beta secretase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2525] [GtoPdb: 2331] [UniProtKB: Q9Y5Z0]
ChEMBL	Inhibition of human BACE2 using MR121-labeled substrate incubated for 4 mins prior to substrate addition measured after 2 mins by spectrophotometric analysis	B	8.05	pIC50	9	nM	IC50	J Med Chem (2013) 56: 3980-3995 [PMID:23590342]
GtoPdb	-	-	8.22	pIC50	6	nM	IC50	Cell Metab (2011) 14: 365-77 [PMID:21907142]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]