INCB3344 [Ligand Id: 777] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2426341
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  • CCR2 in Mouse [GtoPdb: 59] [UniProtKB: P51683]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
C-C motif chemokine 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649052] [UniProtKB: P13500]
ChEMBL Displacement of [3H]INCB3344 from human CCR2 receptor expressed in human U2OS cell membranes B 8.92 pKd 1.2 nM Kd J Med Chem (2013) 56: 7706-7714 [PMID:24028535]
ChEMBL Displacement of [3H]INCB3344 from human CCR2 receptor expressed in human U2OS cell membranes by saturation binding assay B 9.05 pKd 0.9 nM Kd J Med Chem (2013) 56: 7706-7714 [PMID:24028535]
ChEMBL Displacement of [3H]INCB3344 from human CCR2 receptor expressed in human U2OS cell membranes assessed as association and dissociation of compound by competition association assay B 9.14 pKd 0.72 nM Kd J Med Chem (2013) 56: 7706-7714 [PMID:24028535]
ChEMBL Displacement of [3H]INCB3344 from human CCR2 receptor expressed in human U2OS cell membranes assessed as association and dissociation of radioligand B 9.64 pKd 0.23 nM Kd J Med Chem (2013) 56: 7706-7714 [PMID:24028535]
CCR2 in Mouse [GtoPdb: 59] [UniProtKB: P51683]
GtoPdb - - 8 pIC50 - - - J Immunol (2005) 175: 5370-8 [PMID:16210643]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]