ChEMBL ligand: CHEMBL2158051
X-linked inhibitor of apoptosis in Human [GtoPdb: 2790] [UniProtKB: P98170] There should be some charts here, you may need to enable JavaScript!
baculoviral IAP repeat containing 2 in Human [GtoPdb: 2791] [UniProtKB: Q13490] There should be some charts here, you may need to enable JavaScript!
baculoviral IAP repeat containing 3 in Human [GtoPdb: 2792] [UniProtKB: Q13489] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
X-linked inhibitor of apoptosis in Human [GtoPdb: 2790] [UniProtKB: P98170]
GtoPdb	Competitive inhibition of human XIAP BIR3 domain expressed in Escherichia coli.	-	7.18	pKi	66.4	nM	Ki	J Med Chem (2011) 54: 2714-26 [PMID:21443232]
baculoviral IAP repeat containing 2 in Human [GtoPdb: 2791] [UniProtKB: Q13490]
GtoPdb	Competitive inhibition of human cIAP1 BIR3 domain expressed in Escherichia coli.	-	8.72	pKi	1.9	nM	Ki	J Med Chem (2011) 54: 2714-26 [PMID:21443232]
baculoviral IAP repeat containing 3 in Human [GtoPdb: 2792] [UniProtKB: Q13489]
GtoPdb	Competitive inhibition of human cIAP2 BIR3 domain expressed in Escherichia coli.	-	8.29	pKi	5.1	nM	Ki	J Med Chem (2011) 54: 2714-26 [PMID:21443232]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]