AZD5672 [Ligand Id: 7686] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1951914 (Azd5672, Azd 5672, Azd-5672, AZD5672, AZD-5672)
  • CCR5/C-C chemokine receptor type 5 in Human [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CCR5/C-C chemokine receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681]
ChEMBL Antagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxis F 9.16 pIC50 0.69 nM IC50 Bioorg Med Chem Lett (2012) 22: 1655-1659 [PMID:22266038]
ChEMBL Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells B 9.59 pIC50 0.26 nM IC50 Bioorg Med Chem Lett (2012) 22: 1655-1659 [PMID:22266038]
GtoPdb Displacement of [125I]MIP-1α from human recombinant CCR5 expressed in CHO cells - 9.59 pIC50 0.26 nM IC50 Bioorg Med Chem Lett (2012) 22: 1655-9 [PMID:22266038]
ChEMBL Antagonist activity at CCR5 in human whole blood assessed as inhibition of MIP-1beta-induced receptor internalization F 9.12 pA2 0.76 nM A2 Bioorg Med Chem Lett (2012) 22: 1655-1659 [PMID:22266038]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs B 4.62 pIC50 24000 nM IC50 Bioorg Med Chem Lett (2012) 22: 1655-1659 [PMID:22266038]
ChEMBL Inhibition of human ERG by electrophysiological assay B 4.96 pIC50 11000 nM IC50 Bioorg Med Chem Lett (2012) 22: 1655-1659 [PMID:22266038]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]