Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL1951914 (Azd5672, Azd 5672, Azd-5672, AZD5672, AZD-5672) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
CCR5/C-C chemokine receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681] | ||||||||
ChEMBL | Antagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxis | F | 9.16 | pIC50 | 0.69 | nM | IC50 | Bioorg. Med. Chem. Lett. (2012) 22: 1655-1659 [PMID:22266038] |
ChEMBL | Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells | B | 9.59 | pIC50 | 0.26 | nM | IC50 | Bioorg. Med. Chem. Lett. (2012) 22: 1655-1659 [PMID:22266038] |
GtoPdb | Displacement of [125I]MIP-1α from human recombinant CCR5 expressed in CHO cells | - | 9.59 | pIC50 | 0.26 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 1655-9 [PMID:22266038] |
ChEMBL | Antagonist activity at CCR5 in human whole blood assessed as inhibition of MIP-1beta-induced receptor internalization | F | 9.12 | pA2 | 0.76 | nM | A2 | Bioorg. Med. Chem. Lett. (2012) 22: 1655-1659 [PMID:22266038] |
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs | B | 4.62 | pIC50 | 24000 | nM | IC50 | Bioorg. Med. Chem. Lett. (2012) 22: 1655-1659 [PMID:22266038] |
ChEMBL | Inhibition of human ERG by electrophysiological assay | B | 4.96 | pIC50 | 11000 | nM | IC50 | Bioorg. Med. Chem. Lett. (2012) 22: 1655-1659 [PMID:22266038] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]