AZD5672 [Ligand Id: 7686] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1951914 (Azd 5672, Azd-5672, Azd5672, AZD-5672, AZD5672) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCR5/C-C chemokine receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681] | ||||||||
| ChEMBL | Antagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxis | F | 9.16 | pIC50 | 0.69 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 1655-1659 [PMID:22266038] |
| ChEMBL | Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells | B | 9.59 | pIC50 | 0.26 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 1655-1659 [PMID:22266038] |
| GtoPdb | Displacement of [125I]MIP-1α from human recombinant CCR5 expressed in CHO cells | - | 9.59 | pIC50 | 0.26 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 1655-9 [PMID:22266038] |
| ChEMBL | Antagonist activity at CCR5 in human whole blood assessed as inhibition of MIP-1beta-induced receptor internalization | F | 9.12 | pA2 | 0.76 | nM | A2 | Bioorg Med Chem Lett (2012) 22: 1655-1659 [PMID:22266038] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs | B | 4.62 | pIC50 | 24000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 1655-1659 [PMID:22266038] |
| ChEMBL | Inhibition of human ERG by electrophysiological assay | B | 4.96 | pIC50 | 11000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 1655-1659 [PMID:22266038] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
