AZD5672 [Ligand Id: 7686] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1951914 (Azd 5672, Azd-5672, Azd5672, AZD-5672, AZD5672) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCR5/C-C chemokine receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681] | ||||||||
| ChEMBL | Antagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxis | F | 9.16 | pIC50 | 0.69 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 1655-1659 [PMID:22266038] |
| ChEMBL | Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells | B | 9.59 | pIC50 | 0.26 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 1655-1659 [PMID:22266038] |
| GtoPdb | Displacement of [125I]MIP-1α from human recombinant CCR5 expressed in CHO cells | - | 9.59 | pIC50 | 0.26 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 1655-9 [PMID:22266038] |
| ChEMBL | Antagonist activity at CCR5 in human whole blood assessed as inhibition of MIP-1beta-induced receptor internalization | F | 9.12 | pA2 | 0.76 | nM | A2 | Bioorg Med Chem Lett (2012) 22: 1655-1659 [PMID:22266038] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs | B | 4.62 | pIC50 | 24000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 1655-1659 [PMID:22266038] |
| ChEMBL | Inhibition of human ERG by electrophysiological assay | B | 4.96 | pIC50 | 11000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 1655-1659 [PMID:22266038] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
