AZD1981 [Ligand Id: 7680] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1914489 (Azd 1981, AZD-1981, Azd1981)
  • aldo-keto reductase family 1 member B/Aldose reductase in Human [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
  • This target only has 0 pki data point
  • 0
1 CHEMBL1914489_lig_chart_1 Aldose reductase Human
There should be some charts here, you may need to enable JavaScript!
  • DP2 receptor/G protein-coupled receptor 44 in Human [ChEMBL: CHEMBL5071] [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
  • This target only has 0 pki data point
  • 0
2 CHEMBL1914489_lig_chart_2 G protein-coupled receptor 44 Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
ChEMBL Inhibition of human recombinant aldose reductase 1 after 15 mins by spectrophotometry analysis B 6.1 pIC50 794 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6288-6292 [PMID:21944852]
DP2 receptor/G protein-coupled receptor 44 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5071] [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
ChEMBL Antagonist activity against human CRTh2 receptor in human eosinophils assessed as inhibition of DK-PGD2-induced CD11b expression F 8 pIC50 10 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6288-6292 [PMID:21944852]
ChEMBL Displacement of [3H]PGD2 from human CRTH2 receptor B 8.37 pIC50 4.3 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6288-6292 [PMID:21944852]
ChEMBL Displacement of [3H]PGD2 from recombinant human CRTH2 expressed in HEK293 cells after 2 hrs by microbeta scintillation counting B 8.37 pIC50 4.3 nM IC50 J. Med. Chem. (2012) 55: 2915-2931 [PMID:22224640]
GtoPdb Displacement of [3H]PGD2 from human DP2 receptor - 8.37 pIC50 4.3 nM IC50 Bioorg Med Chem Lett (2011) 21: 6288-92 [PMID:21944852]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]