AZD1981 [Ligand Id: 7680] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1914489 (Azd 1981, Azd-1981, Azd1981, AZD-1981) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] | ||||||||
| ChEMBL | Inhibition of human recombinant aldose reductase 1 after 15 mins by spectrophotometry analysis | B | 6.1 | pIC50 | 794 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 6288-6292 [PMID:21944852] |
| DP2 receptor/G protein-coupled receptor 44 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5071] [GtoPdb: 339] [UniProtKB: Q9Y5Y4] | ||||||||
| ChEMBL | Antagonist activity against human CRTh2 receptor in human eosinophils assessed as inhibition of DK-PGD2-induced CD11b expression | F | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 6288-6292 [PMID:21944852] |
| ChEMBL | Displacement of [3H]PGD2 from human CRTH2 receptor | B | 8.37 | pIC50 | 4.3 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 6288-6292 [PMID:21944852] |
| ChEMBL | Displacement of [3H]PGD2 from recombinant human CRTH2 expressed in HEK293 cells after 2 hrs by microbeta scintillation counting | B | 8.37 | pIC50 | 4.3 | nM | IC50 | J Med Chem (2012) 55: 2915-2931 [PMID:22224640] |
| GtoPdb | Displacement of [3H]PGD2 from human DP2 receptor | - | 8.37 | pIC50 | 4.3 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 6288-92 [PMID:21944852] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
