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ChEMBL ligand: CHEMBL1914489 (Azd1981, Azd 1981, Azd-1981, AZD-1981) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] | ||||||||
ChEMBL | Inhibition of human recombinant aldose reductase 1 after 15 mins by spectrophotometry analysis | B | 6.1 | pIC50 | 794 | nM | IC50 | Bioorg. Med. Chem. Lett. (2011) 21: 6288-6292 [PMID:21944852] |
DP2 receptor/G protein-coupled receptor 44 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5071] [GtoPdb: 339] [UniProtKB: Q9Y5Y4] | ||||||||
ChEMBL | Antagonist activity against human CRTh2 receptor in human eosinophils assessed as inhibition of DK-PGD2-induced CD11b expression | F | 8 | pIC50 | 10 | nM | IC50 | Bioorg. Med. Chem. Lett. (2011) 21: 6288-6292 [PMID:21944852] |
ChEMBL | Displacement of [3H]PGD2 from human CRTH2 receptor | B | 8.37 | pIC50 | 4.3 | nM | IC50 | Bioorg. Med. Chem. Lett. (2011) 21: 6288-6292 [PMID:21944852] |
ChEMBL | Displacement of [3H]PGD2 from recombinant human CRTH2 expressed in HEK293 cells after 2 hrs by microbeta scintillation counting | B | 8.37 | pIC50 | 4.3 | nM | IC50 | J. Med. Chem. (2012) 55: 2915-2931 [PMID:22224640] |
GtoPdb | Displacement of [3H]PGD2 from human DP2 receptor | - | 8.37 | pIC50 | 4.3 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 6288-92 [PMID:21944852] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]