ML277 [Ligand Id: 7666] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2070953 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv7.1/Potassium voltage-gated channel subfamily KQT member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1866] [GtoPdb: 560] [UniProtKB: P51787] | ||||||||
| ChEMBL | Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay | B | 6.59 | pEC50 | 260 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 5936-5941 [PMID:22910039] |
| GtoPdb | - | - | 6.6 | pEC50 | 260 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 5936-41 [PMID:22910039] |
| Kv7.2/Potassium voltage-gated channel subfamily KQT member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2476] [GtoPdb: 561] [UniProtKB: O43526] | ||||||||
| ChEMBL | Activation of KCNQ2 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay relative to control | B | 4.52 | pEC50 | >30000 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 5936-5941 [PMID:22910039] |
| Kv7.4/Potassium voltage-gated channel subfamily KQT member 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3576] [GtoPdb: 563] [UniProtKB: P56696] | ||||||||
| ChEMBL | Activation of KCNQ4 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay relative to control | B | 4.52 | pEC50 | >30000 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 5936-5941 [PMID:22910039] |
| Kv11.1/Voltage-gated inwardly rectifying potassium channel KCNH2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG expressed in CHO cells after 3 mins by patch clamp assay | B | 4.52 | pIC50 | >30000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5936-5941 [PMID:22910039] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
