Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL430060 (Acipidin) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
coagulation factor III, tissue factor/Coagulation factor III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4081] [GtoPdb: 3192] [UniProtKB: P13726] | ||||||||
ChEMBL | Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotting assay | B | 6.7 | pIC50 | 200 | nM | IC50 | J Biol Chem (2007) 282: 28408-28418 [PMID:17675290] |
ChEMBL | Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay | B | 6.82 | pIC50 | 150 | nM | IC50 | J Biol Chem (2007) 282: 28408-28418 [PMID:17675290] |
Histone deacetylase in Cryptosporidium parvum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4740] [UniProtKB: Q9GU59] | ||||||||
ChEMBL | Binding affinity towards HDAC enzyme derived from Eimeria tenella protozoa | B | 8.1 | pKi | 8 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 113-117 [PMID:11206439] |
ChEMBL | Tested for Histone deacetylase enzyme inhibition assay using Eimeria tenella extract | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2000) 43: 4919-4922 [PMID:11124001] |
Histone deacetylase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5541] [UniProtKB: Q9XYC7] | ||||||||
ChEMBL | Inhibition of Plasmodium falciparum HDAC1 expressed in Drosophila melanogaster S2 cells | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2009) 52: 2185-2187 [PMID:19317450] |
histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] | ||||||||
ChEMBL | Inhibition of human HDAC1 | B | 10.4 | pKi | 0.04 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
GtoPdb | - | - | 10.4 | pKi | 0.04 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
ChEMBL | Inhibition of HDAC1 (mean IC50) | B | 7.36 | pIC50 | 44 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5948-5952 [PMID:16987657] |
ChEMBL | Inhibition of HDAC1 | B | 7.36 | pIC50 | 44 | nM | IC50 | J Med Chem (2008) 51: 2350-2353 [PMID:18370373] |
ChEMBL | Inhibition of human recombinant C-terminally flag tagged HDAC1 | B | 7.36 | pIC50 | 44 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5528-5532 [PMID:18809328] |
ChEMBL | Inhibition of C-terminal FLAG tagged HDAC1 | B | 7.36 | pIC50 | 44 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3081-3084 [PMID:19410459] |
ChEMBL | Inhibition of HDAC1 in human NIH3T3 cells by radiometric histone deacetylation assay | B | 7.36 | pIC50 | 44 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3651-3656 [PMID:19457659] |
ChEMBL | Inhibition of HDAC1 in HEK293 cells | B | 7.64 | pIC50 | 23 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563] |
ChEMBL | Inhibition of HDAC1 (unknown origin) | B | 7.66 | pIC50 | 22 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462] |
ChEMBL | Inhibition of human recombinant HDAC1 after 30 mins by fluorimetric assay | B | 7.66 | pIC50 | 22 | nM | IC50 | J Med Chem (2009) 52: 7836-7846 [PMID:19705846] |
ChEMBL | Inhibition of HDAC1 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry | B | 7.66 | pIC50 | 22 | nM | IC50 | ACS Med Chem Lett (2011) 2: 703-707 [PMID:21984958] |
ChEMBL | Inhibition of HDAC1 | B | 7.89 | pIC50 | 13 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2549-2554 [PMID:18381239] |
ChEMBL | Inhibition of human recombinant HDAC1 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay | B | 7.96 | pIC50 | 11 | nM | IC50 | ACS Med Chem Lett (2012) 3: 749-753 [PMID:24900543] |
ChEMBL | Inhibition of HDAC1 | B | 9.15 | pIC50 | 0.7 | nM | IC50 | Bioorg Med Chem (2010) 18: 4103-4110 [PMID:20472442] |
histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] | ||||||||
GtoPdb | - | - | 9.92 | pKi | 0.12 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
ChEMBL | Inhibition of human HDAC2 | B | 9.92 | pKi | 0.12 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
ChEMBL | Inhibition of recombinant HDAC2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis | B | 7.46 | pIC50 | 35 | nM | IC50 | ACS Med Chem Lett (2012) 3: 505-508 [PMID:24900500] |
ChEMBL | Inhibition of HDAC2 (unknown origin) | B | 7.46 | pIC50 | 35 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462] |
ChEMBL | Inhibition of human recombinant HDAC2 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay | B | 7.47 | pIC50 | 34 | nM | IC50 | ACS Med Chem Lett (2012) 3: 749-753 [PMID:24900543] |
ChEMBL | Inhibition of HDAC2 | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem (2010) 18: 4103-4110 [PMID:20472442] |
GtoPdb | - | - | 6.92 | pEC50 | 120 | nM | EC50 | Biochem J (2008) 409: 581-9 [PMID:17868033] |
histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] | ||||||||
ChEMBL | Inhibition of human HDAC3 | B | 9.59 | pKi | 0.26 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
GtoPdb | - | - | 9.59 | pKi | 0.26 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
ChEMBL | Inhibition of human recombinant HDAC3 after 30 mins by fluorimetric assay | B | 7.54 | pIC50 | 29 | nM | IC50 | J Med Chem (2009) 52: 7836-7846 [PMID:19705846] |
ChEMBL | Inhibition of HDAC3 (unknown origin) | B | 7.54 | pIC50 | 29 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462] |
ChEMBL | Inhibition of HDAC3 in HEK293 cells | B | 8.01 | pIC50 | 9.7 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563] |
ChEMBL | Inhibition of flag-tagged HDAC3 | B | 8.6 | pIC50 | 2.5 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988] |
ChEMBL | Inhibition of HDAC3 | B | 9.22 | pIC50 | 0.6 | nM | IC50 | Bioorg Med Chem (2010) 18: 4103-4110 [PMID:20472442] |
GtoPdb | - | - | 7.37 | pEC50 | 43 | nM | EC50 | Biochem J (2008) 409: 581-9 [PMID:17868033] |
GtoPdb | - | - | 7.52 | pEC50 | 30 | nM | EC50 | Biochem J (2008) 409: 581-9 [PMID:17868033] |
histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379, Q9Y618] | ||||||||
ChEMBL | Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC3/NcoR2 by fluorescence polarization assay | B | 8.82 | pKi | 1.5 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569] |
GtoPdb | - | - | 9.59 | pKi | 0.26 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
ChEMBL | Inhibition of HDAC3-NCoR2 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry | B | 7.54 | pIC50 | 29 | nM | IC50 | ACS Med Chem Lett (2011) 2: 703-707 [PMID:21984958] |
ChEMBL | Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC3/NcoR2 by fluorescence polarization assay | B | 7.8 | pIC50 | 15.8 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569] |
ChEMBL | Inhibition of human recombinant HDAC3/NCoR2 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay | B | 7.89 | pIC50 | 13 | nM | IC50 | ACS Med Chem Lett (2012) 3: 749-753 [PMID:24900543] |
GtoPdb | - | - | 7.37 | pEC50 | 43 | nM | EC50 | Biochem J (2008) 409: 581-9 [PMID:17868033] |
GtoPdb | - | - | 7.52 | pEC50 | 30 | nM | EC50 | Biochem J (2008) 409: 581-9 [PMID:17868033] |
histone deacetylase 4/Histone deacetylase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524] | ||||||||
ChEMBL | Inhibition of wild type HDAC4 expressed in Escherichia coli | B | 5.06 | pIC50 | 8700 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563] |
ChEMBL | Inhibition of HDAC4 H976Y mutant expressed in Escherichia coli | B | 5.44 | pIC50 | 3600 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563] |
ChEMBL | Inhibition of flag-tagged HDAC4 by pull-down assay | B | 8.62 | pIC50 | 2.4 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988] |
ChEMBL | Inhibition of flag-tagged HDAC4 by Biomol assay | B | 8.92 | pIC50 | 1.2 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988] |
ChEMBL | Inhibition of flag-tagged HDAC4 | B | 9 | pIC50 | 1 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988] |
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
ChEMBL | Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC6 by fluorescence polarization assay | B | 6.91 | pKi | 123.4 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569] |
ChEMBL | Inhibition of HDAC6 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry | B | 5 | pIC50 | >10000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 703-707 [PMID:21984958] |
ChEMBL | Inhibition of HDAC6 (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462] |
ChEMBL | Inhibition of human recombinant HDAC6 after 30 mins by fluorimetric assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2009) 52: 7836-7846 [PMID:19705846] |
ChEMBL | Inhibition of human recombinant HDAC6 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay | B | 5 | pIC50 | >10000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 749-753 [PMID:24900543] |
ChEMBL | Inhibition of HDAC6 | B | 5.02 | pIC50 | 9600 | nM | IC50 | Bioorg Med Chem (2010) 18: 4103-4110 [PMID:20472442] |
ChEMBL | Inhibition of HDAC6 in HEK293 cells | B | 5.37 | pIC50 | 4300 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563] |
ChEMBL | Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC6 by fluorescence polarization assay | B | 6.18 | pIC50 | 665.1 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569] |
histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] | ||||||||
ChEMBL | Activity of human HDAC8 | B | 7.31 | pKi | 49 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
GtoPdb | - | - | 7.31 | pKi | 49 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
ChEMBL | Inhibition of human recombinant HDAC8 after 30 mins by fluorimetric assay | B | 6.12 | pIC50 | 760 | nM | IC50 | J Med Chem (2009) 52: 7836-7846 [PMID:19705846] |
ChEMBL | Inhibition of HDAC8 (unknown origin) | B | 6.12 | pIC50 | 760 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462] |
ChEMBL | Inhibition of HDAC8 in human HeLa cells nuclear extract using Arg-His-Lys(Ac)-Lys(Ac)-AMC as substrate after 30 mins by spectrophotometry | B | 6.12 | pIC50 | 755 | nM | IC50 | ACS Med Chem Lett (2011) 2: 703-707 [PMID:21984958] |
ChEMBL | Inhibition of human recombinant HDAC8 using Arg-His-Lys(Ac)-Lys(Ac)-AMC as substrate after 30 mins by trypsin-coupled fluorogenic assay | B | 6.12 | pIC50 | 750 | nM | IC50 | ACS Med Chem Lett (2012) 3: 749-753 [PMID:24900543] |
ChEMBL | Inhibition of HDAC8 | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem (2010) 18: 4103-4110 [PMID:20472442] |
GtoPdb | - | - | 6.24 | pEC50 | 575 | nM | EC50 | Biochem J (2008) 409: 581-9 [PMID:17868033] |
Histone deacetylase-like amidohydrolase in Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6017] [UniProtKB: Q70I53] | ||||||||
ChEMBL | Displacement of Atto700-HA from Bordetella / Alcaligenes strain FB188 HDAH by fluorescence anisotropy | B | 5.04 | pKi | 9200 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 3651-3656 [PMID:19457659] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as parasite growth inhibition after 48 hrs by light microscopic analysis | F | 6.7 | pIC50 | 200 | nM | IC50 | J Nat Prod (2013) 76: 2136-2140 [PMID:24195442] |
ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as reduction in parasite growth after 48 hrs by light microscopic analysis | F | 6.7 | pIC50 | 200 | nM | IC50 | J Nat Prod (2022) 85: 2641-2649 [PMID:36282784] |
ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake | F | 7.48 | pIC50 | 33 | nM | IC50 | J Med Chem (2009) 52: 2185-2187 [PMID:19317450] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]