arformoterol [Ligand Id: 7479] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1363 (Arformoterol, (-)-formoterol, Formoterol r,r-form, (r,r)-formoterol) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| ChEMBL | Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology | F | 6.96 | pEC50 | 109 | nM | EC50 | J Med Chem (2020) 63: 15218-15242 [PMID:33213146] |
| β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| ChEMBL | Agonist activity at human beta2 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology | F | 8.58 | pEC50 | 2.63 | nM | EC50 | J Med Chem (2020) 63: 15218-15242 [PMID:33213146] |
| ChEMBL | Agonist activity at beta2-adrenergic receptor (unknown origin) | F | 9.5 | pEC50 | 0.32 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 249-253 [PMID:24300734] |
| Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4] | ||||||||
| ChEMBL | Agonist activity at guinea pig trachea beta2-adrenergic receptor assessed as relaxation of histamine-induced tracheal ring contraction | B | 9.89 | pEC50 | 0.13 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 249-253 [PMID:24300734] |
| ChEMBL | Agonist activity at guinea pig trachea beta2-adrenergic receptor assessed as relaxation of histamine-induced tracheal ring contraction | B | 9.9 | pEC50 | 0.13 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 249-253 [PMID:24300734] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
