ChEMBL ligand: CHEMBL266497 (CP-45,634, CP-45634, NSC-355082, Sorbinil, Sorbinilo)
Aldehyde reductase in Human [ChEMBL: CHEMBL2246] [UniProtKB: P14550] Aldehyde reductase in Pig [ChEMBL: CHEMBL4049] [UniProtKB: P50578] Aldehyde reductase in Rat [ChEMBL: CHEMBL3871] [UniProtKB: P51635] There should be some charts here, you may need to enable JavaScript!
Aldo-keto reductase family 1 member B10 in Human [ChEMBL: CHEMBL5983] [UniProtKB: O60218] There should be some charts here, you may need to enable JavaScript!
aldo-keto reductase family 1 member B/Aldose reductase in Human [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] Aldose reductase in Pig [ChEMBL: CHEMBL4559] [UniProtKB: P80276] Aldose reductase in Bovine [ChEMBL: CHEMBL3081] [UniProtKB: P16116] aldo-keto reductase family 1 member B/Aldose reductase in Rat [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Aldehyde reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2246] [UniProtKB: P14550]
ChEMBL	Tested for in vitro inhibition activity against human aldehyde reductase (AHR)	B	5.27	pIC50	5400	nM	IC50	J Med Chem (2000) 43: 2479-2483 [PMID:10882376]
ChEMBL	Inhibitory concentration against human ALR1 Aldehyde reductase using DL-glyceraldehyde	B	5.27	pIC50	5400	nM	IC50	J Med Chem (2005) 48: 5536-5542 [PMID:16107153]
ChEMBL	Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reduction	B	5.34	pIC50	4600	nM	IC50	Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656]
ChEMBL	Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using DL-glyceraldehyde as substrate	B	5.92	pIC50	1200	nM	IC50	J Med Chem (2023) 66: 5657-5668 [PMID:37027003]
Aldehyde reductase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4049] [UniProtKB: P50578]
ChEMBL	Inhibitory concentration against porcine ALR1 Aldehyde reductase using DL-glyceraldehyde	B	5.4	pIC50	4000	nM	IC50	J Med Chem (2005) 48: 5536-5542 [PMID:16107153]
ChEMBL	Inhibitory activity measured against pig kidney aldehyde reductase using 3-pyridinecarboxaldehyde as substrate	B	5.72	pIC50	1900	nM	IC50	J Med Chem (1991) 34: 1011-1018 [PMID:1900532]
Aldehyde reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3871] [UniProtKB: P51635]
ChEMBL	Evaluated for inhibition of Aldehyde reductase 1	B	5.76	pIC50	1740	nM	IC50	J Med Chem (1996) 39: 4396-4405 [PMID:8893834]
ChEMBL	In vitro inhibitory activity against aldehyde reductase 1 (ALR1) from rat kidney.	B	7.54	pIC50	29	nM	IC50	J Med Chem (2003) 46: 1419-1428 [PMID:12672241]
Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218]
ChEMBL	Inhibition of reductase activity of N-terminal 6His-tagged AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as inhibition of NADPH linked pyridine-3-aldehyde reduction	B	5.02	pIC50	9600	nM	IC50	Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656]
aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
ChEMBL	Inhibitory activity against human placenta aldose reductase	B	4.7	pIC50	20000	nM	IC50	J Med Chem (1985) 28: 1716-1720 [PMID:3934383]
ChEMBL	Inhibitory activity against human placental aldose reductase in Sepharose 4B column at day 7	B	5.14	pIC50	7200	nM	IC50	J Med Chem (1985) 28: 841-849 [PMID:3925146]
GtoPdb	-	-	5.27	pIC50	5400	nM	IC50	J Med Chem (2000) 43: 2479-83 [PMID:10882376]
ChEMBL	Inhibitory activity against human placental aldose reductase in Sepharose 4B column at time 1	B	5.33	pIC50	4700	nM	IC50	J Med Chem (1985) 28: 841-849 [PMID:3925146]
ChEMBL	In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determined	B	5.44	pIC50	3600	nM	IC50	J Med Chem (2003) 46: 5208-5221 [PMID:14613323]
ChEMBL	Inhibition of ALR2 (unknown origin)	B	5.5	pIC50	3140	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127664-127664 [PMID:33152379]
ChEMBL	Tested for in vitro inhibition activity against human Aldose reductase (human AR)	B	5.7	pIC50	2000	nM	IC50	J Med Chem (2000) 43: 2479-2483 [PMID:10882376]
ChEMBL	Inhibition of recombinant human ALR2 using D,L-glyceraldehyde and NADPH as substrate preincubated for 3 mins followed by substrate addition and measured for 3 mins by spectrophotometric analysis	B	5.7	pIC50	2000	nM	IC50	Bioorg Med Chem Lett (2016) 26: 4870-4874 [PMID:27666634]
ChEMBL	Inhibition of aldose reductase	B	5.7	pIC50	2000	nM	IC50	Bioorg Med Chem (2007) 15: 7865-7877 [PMID:17870536]
ChEMBL	Inhibitory concentration against human ALR2	B	5.7	pIC50	2000	nM	IC50	J Med Chem (2005) 48: 5536-5542 [PMID:16107153]
ChEMBL	Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.7M DMSO followed by compound addition by DMSO-perturbation assay	B	5.8	pIC50	1580	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126815-126815 [PMID:31744675]
ChEMBL	Inhibitory activity against human placenta aldose reductase	B	6	pIC50	1000	nM	IC50	J Med Chem (1985) 28: 1716-1720 [PMID:3934383]
ChEMBL	Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.3M DMSO followed by compound addition by DMSO-perturbation assay	B	6.01	pIC50	971	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126815-126815 [PMID:31744675]
ChEMBL	Inhibitory Activity against Human recombinant Aldose Reductase (wild type)	B	6.04	pIC50	918.6	nM	IC50	J Med Chem (2000) 43: 1062-1070 [PMID:10737739]
ChEMBL	Inhibition of human recombinant aldose reductase	B	6.04	pIC50	910	nM	IC50	Bioorg Med Chem (2008) 16: 3245-3254 [PMID:18165015]
ChEMBL	Inhibition of human recombinant ALR2 expressed in Escherichia coli using DL-glyceraldehyde as substrate and NADPH preincubated for 5 mins followed by substrate addition and measured after 30 mins at 2 mins interval by spectrophotometry relative to control	B	6.12	pIC50	750	nM	IC50	Eur J Med Chem (2019) 168: 154-175 [PMID:30818176]
ChEMBL	Inhibitory activity against human placental aldose reductase in 30 -70% (NH4)2SO4.	B	6.15	pIC50	700	nM	IC50	J Med Chem (1985) 28: 841-849 [PMID:3925146]
ChEMBL	Inhibition of ARL2 (unknown origin)	B	6.19	pIC50	650	nM	IC50	RSC Med Chem (2023) 14: 823-847 [PMID:37252095]
ChEMBL	Inhibition of N-terminal 6His-tagged human aldose reductase expressed in Escherichia coli BL21(DE3) mediated NADPH linked pyridine-3-aldehyde reduction	B	6.26	pIC50	550	nM	IC50	Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656]
ChEMBL	In vitro inhibitory activity towards human placenta aldose reductase	B	6.3	pIC50	500	nM	IC50	J Med Chem (1988) 31: 230-243 [PMID:3121857]
ChEMBL	Inhibitory activity against human placental aldose reductase (HPAR) with glyceraldehyde as substrate	B	6.3	pIC50	500	nM	IC50	J Med Chem (1989) 32: 1208-1213 [PMID:2498517]
ChEMBL	Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens	B	6.6	pIC50	250	nM	IC50	J Med Chem (1992) 35: 2085-2094 [PMID:1597858]
ChEMBL	Inhibition of aldose reductase	B	6.6	pIC50	249	nM	IC50	Eur J Med Chem (2010) 45: 1663-1666 [PMID:20071057]
ChEMBL	In vitro inhibitory activity against Aldose reductase isolated from human placenta	F	6.77	pIC50	170	nM	IC50	J Med Chem (1990) 33: 1859-1865 [PMID:2113948]
ChEMBL	In vitro inhibitroy concentration against Aldose reductase incubated at 24 degree C for 15 minutes in pH 7.0	B	6.85	pIC50	140	nM	IC50	J Med Chem (2005) 48: 6326-6339 [PMID:16190759]
ChEMBL	In vitro inhibitory activity against human recombinant Aldose reductase in streptozotocin diabetic rat at 50 mg/kg	B	6.85	pIC50	140	nM	IC50	J Med Chem (2003) 46: 2283-2286 [PMID:12773033]
ChEMBL	Inhibition of human placental aldose reductase (HPAR) activity with glyceraldehyde as substrate	B	6.92	pIC50	120	nM	IC50	J Med Chem (1989) 32: 1208-1213 [PMID:2498517]
ChEMBL	Inhibition of aldose reductase	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem (2010) 18: 2107-2114 [PMID:20189816]
ChEMBL	In vitro inhibition of rabbit lens aldose reductase.	B	7.17	pIC50	67	nM	IC50	J Med Chem (1986) 29: 2347-2351 [PMID:3097317]
Aldose reductase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4559] [UniProtKB: P80276]
ChEMBL	Inhibition of aldose reductase from pig lenses	B	5.96	pIC50	1100	nM	IC50	J Med Chem (2004) 47: 5076-5084 [PMID:15456251]
Aldose reductase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3081] [UniProtKB: P16116]
ChEMBL	Inhibitory activity against bovine lens aldose reductase	B	5.36	pIC50	4400	nM	IC50	J Med Chem (1985) 28: 1716-1720 [PMID:3934383]
ChEMBL	Inhibition of ALR2 in calf lenses using DL-glyceraldehyde as substrate treated with compound for 10 mins prior to substrate addition by UV spectrophotometer analysis	B	5.5	pIC50	3140	nM	IC50	Eur J Med Chem (2015) 98: 127-138 [PMID:26005026]
ChEMBL	Evaluated for inhibition of Aldose reductase 2	B	5.52	pIC50	3040	nM	IC50	J Med Chem (1996) 39: 4396-4405 [PMID:8893834]
ChEMBL	In vitro inhibitory activity against Aldose reductase 2 obtained from calf lenses	B	5.52	pIC50	3040	nM	IC50	J Med Chem (1999) 42: 1894-1900 [PMID:10354397]
ChEMBL	Inhibition of bovine lens aldose reductase	B	5.7	pIC50	2000	nM	IC50	Bioorg Med Chem (2010) 18: 4049-4055 [PMID:20452228]
ChEMBL	Inhibition of bovine aldose reductase assessed as oxidation of NADPH	B	5.7	pIC50	2000	nM	IC50	Eur J Med Chem (2014) 81: 1-14 [PMID:24819954]
ChEMBL	Inhibition of bovine lens ALR2	B	5.7	pIC50	2000	nM	IC50	Eur J Med Chem (2011) 46: 2797-2806 [PMID:21531055]
ChEMBL	Inhibition of bovine lens aldose reductase assessed as inhibition of NDAPH oxidation by non-linear regression analysis	B	5.7	pIC50	2000	nM	IC50	Bioorg Med Chem Lett (2011) 21: 200-203 [PMID:21129963]
ChEMBL	Inhibition of Aldose reductase 2 of bovine lens	B	5.73	pIC50	1850	nM	IC50	J Med Chem (1999) 42: 1881-1893 [PMID:10354396]
ChEMBL	The compound was tested for Inhibitory effect against Aldose reductase 1 in bovine kidneys	B	5.81	pIC50	1560	nM	IC50	J Med Chem (1999) 42: 1881-1893 [PMID:10354396]
ChEMBL	Inhibition of bovine lens aldose reductase with DL-glyceraldehyde as substrate	B	5.82	pIC50	1500	nM	IC50	J Med Chem (1984) 27: 255-256 [PMID:6422042]
ChEMBL	Inhibition of bovine lens ALR2 assessed as reduction of D,L-glyceraldehyde by spectrophotometry	B	5.85	pIC50	1410	nM	IC50	Bioorg Med Chem (2008) 16: 5840-5852 [PMID:18492610]
ChEMBL	Inhibition of bovine aldose reductase	B	5.85	pIC50	1410	nM	IC50	Bioorg Med Chem Lett (2007) 17: 3886-3893 [PMID:17512196]
ChEMBL	In vitro % decrease of aldose reductase was measured in isolated partially purified bovine lens preparations at 10e-7 M concentration	B	5.96	pIC50	1100	nM	IC50	J Med Chem (1991) 34: 2504-2520 [PMID:1908522]
ChEMBL	In vitro % decrease of aldose reductase was measured in isolated partially purified bovine lens preparations at 10e-6 M concentration	B	5.96	pIC50	1100	nM	IC50	J Med Chem (1991) 34: 2504-2520 [PMID:1908522]
ChEMBL	In vitro inhibition of partially purified calf lens aldose reductase	B	6	pIC50	1000	nM	IC50	J Med Chem (1988) 31: 230-243 [PMID:3121857]
ChEMBL	Inhibitory activity against bovine lens aldose reductase	B	6.82	pIC50	150	nM	IC50	J Med Chem (1985) 28: 1716-1720 [PMID:3934383]
aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943]
ChEMBL	Inhibitory activity against rat lens aldose reductase	B	5.05	pIC50	9000	nM	IC50	J Med Chem (1985) 28: 1716-1720 [PMID:3934383]
ChEMBL	Inhibition of aldose reductase in rat lens by spectrophotometer analysis	B	5.1	pIC50	8000	nM	IC50	Eur J Med Chem (2014) 80: 209-217 [PMID:24780598]
ChEMBL	Inhibition of rat kidney ALR1 using DL-glyceraldehyde as substrate and NADPH preincubated for 5 mins followed by substrate addition and measured for 30 mins at 2 mins interval by spectrophotometry relative to control	B	5.34	pIC50	4570	nM	IC50	Eur J Med Chem (2019) 168: 154-175 [PMID:30818176]
ChEMBL	Inhibition of Sprague-Dawley rat lens ALR2 using D,L-glyceraldehyde as substrate preincubated for 10 mins followed by substrate addition measured for 5 mins by spectrophotometric method	B	5.7	pIC50	2000	nM	IC50	Bioorg Med Chem (2017) 25: 3068-3076 [PMID:28392277]
ChEMBL	In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)	B	6	pIC50	990	nM	IC50	J Med Chem (1991) 34: 3229-3234 [PMID:1956041]
ChEMBL	Inhibitory concentration against rat ALR2 aldose reductase	B	6.05	pIC50	900	nM	IC50	J Med Chem (2005) 48: 5536-5542 [PMID:16107153]
ChEMBL	Tested for in vitro inhibition activity against rat Aldose reductase (AR)	B	6.05	pIC50	900	nM	IC50	J Med Chem (2000) 43: 2479-2483 [PMID:10882376]
ChEMBL	In vitro inhibitory activity against aldose reductase (ALR2) from rat lens extraction.	B	6.19	pIC50	650	nM	IC50	J Med Chem (2003) 46: 1419-1428 [PMID:12672241]
ChEMBL	Inhibitory concentration to aldose reductase (ALR-2) obtained from rat lens	B	6.19	pIC50	650	nM	IC50	J Med Chem (2001) 44: 4359-4369 [PMID:11728182]
ChEMBL	Inhibition of Albino rat eye lens ALR2 assessed as NADPH oxidation by spectrophotometry	B	6.21	pIC50	620	nM	IC50	Eur J Med Chem (2010) 45: 909-914 [PMID:19962793]
ChEMBL	In vitro inhibitory activity against aldose reductase (ALR2) from rat lens extraction.	B	6.3	pIC50	500	nM	IC50	J Med Chem (2003) 46: 1419-1428 [PMID:12672241]
ChEMBL	Inhibition of rat lenses ALR2 using DL-glyceraldehyde as substrate preincubated for 10 mins followed by substrate addition measured for 4 mins	B	6.37	pIC50	430	nM	IC50	Eur J Med Chem (2016) 124: 750-762 [PMID:27639366]
ChEMBL	Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrate	B	6.55	pIC50	280	nM	IC50	J Med Chem (1991) 34: 1011-1018 [PMID:1900532]
ChEMBL	In vitro inhibitory activity of compound against rat lens aldose reductase	B	6.6	pIC50	250	nM	IC50	J Med Chem (2004) 47: 2706-2709 [PMID:15115413]
ChEMBL	Inhibition of aldose reductase in Fischer-344 rat lens homogenate by spectrometric analysis	B	6.6	pIC50	250	nM	IC50	Bioorg Med Chem (2010) 18: 2107-2114 [PMID:20189816]
ChEMBL	Inhibition of rat lens ALR2	B	6.6	pIC50	250	nM	IC50	J Med Chem (2010) 53: 7756-7766 [PMID:20936791]
ChEMBL	Inhibition of Fischer-344 rat lens ALR2 using D-glycuronate as substrate by spectrophotometry	B	6.6	pIC50	250	nM	IC50	Bioorg Med Chem (2013) 21: 869-873 [PMID:23312612]
ChEMBL	Inhibition of partially purified Fischer-344 rat lens ALR2 using D,L-glyceraldehyde as substrate assessed as NADPH consumption by spectrophotometry	B	6.6	pIC50	250	nM	IC50	Bioorg Med Chem (2013) 21: 4951-4957 [PMID:23891165]
ChEMBL	Inhibition of Fischer-344 rat lens ALR2 using D, L-glyceraldehyde as substrate by spectrophotometry	B	6.6	pIC50	250	nM	IC50	Bioorg Med Chem (2014) 22: 2194-2207 [PMID:24630695]
ChEMBL	Inhibition of aldose reductase in rat lenses	B	6.6	pIC50	249	nM	IC50	Bioorg Med Chem (2008) 16: 3926-3932 [PMID:18267362]
ChEMBL	Inhibition of aldose reductase from rat lens. Value ranges from 0.07 - 1.2	B	6.64	pIC50	230	nM	IC50	J Med Chem (1989) 32: 1033-1038 [PMID:2496229]
ChEMBL	Inhibitory activity against rat lens aldose reductase	B	6.7	pIC50	200	nM	IC50	J Med Chem (1985) 28: 1716-1720 [PMID:3934383]
ChEMBL	Inhibitory activity against aldose reductase in rat lens	B	6.72	pIC50	190	nM	IC50	J Med Chem (1991) 34: 2120-2126 [PMID:1906108]
ChEMBL	Inhibitory concentration against aldose reductase obtained from rat lens	B	6.74	pIC50	180	nM	IC50	J Med Chem (1989) 32: 145-151 [PMID:2491890]
ChEMBL	In vitro inhibition of Aldose reductase (AR) from rat lens (RL)	B	7	pIC50	100	nM	IC50	J Med Chem (1991) 34: 3229-3234 [PMID:1956041]
ChEMBL	Concentration required to produce 50% inhibition of aldose reductase enzyme (the literature IC50 value for sorbinil is 0.07 uM)	B	7.14	pIC50	73	nM	IC50	J Med Chem (1987) 30: 1595-1598 [PMID:3114491]
ChEMBL	The compound was tested for the inhibition of Aldose reductase in rat lens assay.	B	7.15	pIC50	70	nM	IC50	J Med Chem (1991) 34: 2120-2126 [PMID:1906108]
ChEMBL	Compound was tested for its ability to inhibit crude aldose reductase obtained from rat lens	B	7.7	pIC50	20	nM	IC50	J Med Chem (1986) 29: 627-629 [PMID:3084783]
ChEMBL	Compound was tested for inhibitory concentration against rat lens aldose reductase (uncompetitive inhibition type)	B	7.77	pIC50	17	nM	IC50	J Med Chem (1986) 29: 1094-1099 [PMID:3086557]
ChEMBL	Inhibition of crude aldose reductase of rat lens	B	7.77	pIC50	17	nM	IC50	J Med Chem (1986) 29: 2024-2028 [PMID:3093680]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]