lidorestat [Ligand Id: 7411] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL363387 (EML 676, EML-676, IDD-000676, IDD-000676-01, IDD 676, IDD-676, Lidorestat, Lidorestat anhydrous, Lindolrestat, Lindorestat) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Aldehyde reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2246] [UniProtKB: P14550] | ||||||||
| ChEMBL | In vitro inhibition of recombinant human aldehyde reductase | B | 4.57 | pIC50 | 27000 | nM | IC50 | J Med Chem (2005) 48: 3141-3152 [PMID:15857120] |
| aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] | ||||||||
| ChEMBL | Inhibition of human recombinant aldose reductase 1 after 10 mins by spectrophotometry analysis | B | 4.57 | pIC50 | 27000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2006-2008 [PMID:19250825] |
| GtoPdb | In vitro inhibition of recombinant human aldose reductase expressed in E coli. | - | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2005) 48: 3141-52 [PMID:15857120] |
| ChEMBL | In vitro inhibition of recombinant human aldose reductase expressed in Escherichia coli | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2005) 48: 3141-3152 [PMID:15857120] |
| ChEMBL | Inhibition of aldose reductase | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem (2007) 15: 7865-7877 [PMID:17870536] |
| aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] | ||||||||
| ChEMBL | Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometry | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2015) 58: 2649-2657 [PMID:25695864] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
