ChEMBL ligand: CHEMBL436 (Alderase, Alredase, AY-27,773, AY-27773, Tolrestat)
Aldehyde reductase in Human [ChEMBL: CHEMBL2246] [UniProtKB: P14550] Aldehyde reductase in Pig [ChEMBL: CHEMBL4049] [UniProtKB: P50578] Aldehyde reductase in Rat [ChEMBL: CHEMBL3871] [UniProtKB: P51635] There should be some charts here, you may need to enable JavaScript!
Aldo-keto reductase family 1 member B10 in Human [ChEMBL: CHEMBL5983] [UniProtKB: O60218] There should be some charts here, you may need to enable JavaScript!
Aldo-keto reductase family 1 member C21 in Mouse [ChEMBL: CHEMBL1075270] [UniProtKB: Q91WR5] There should be some charts here, you may need to enable JavaScript!
aldo-keto reductase family 1 member B/Aldose reductase in Human [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] Aldose reductase in Pig [ChEMBL: CHEMBL4559] [UniProtKB: P80276] Aldose reductase in Bovine [ChEMBL: CHEMBL3081] [UniProtKB: P16116] aldo-keto reductase family 1 member B/Aldose reductase in Rat [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Aldehyde reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2246] [UniProtKB: P14550]
ChEMBL	In vitro inhibition of recombinant human aldehyde reductase	B	5.71	pIC50	1940	nM	IC50	J Med Chem (2005) 48: 3141-3152 [PMID:15857120]
ChEMBL	Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reduction	B	6.14	pIC50	720	nM	IC50	Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656]
Aldehyde reductase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4049] [UniProtKB: P50578]
ChEMBL	Inhibition of pig ALR1	B	5.66	pIC50	2190	nM	IC50	Bioorg Med Chem (2009) 17: 1244-1250 [PMID:19121944]
ChEMBL	Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase values	B	6.27	pIC50	540	nM	IC50	J Med Chem (1991) 34: 1011-1018 [PMID:1900532]
Aldehyde reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3871] [UniProtKB: P51635]
ChEMBL	Evaluated for inhibition of Aldehyde reductase 1	B	5.92	pIC50	1210	nM	IC50	J Med Chem (1996) 39: 4396-4405 [PMID:8893834]
Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218]
ChEMBL	Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde reduction	B	7.3	pKi	50	nM	Ki	J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
ChEMBL	Inhibition of reductase activity of N-terminal 6His-tagged AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as inhibition of NADPH linked pyridine-3-aldehyde reduction	B	7.27	pIC50	54	nM	IC50	Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656]
ChEMBL	Inhibition of human N-terminal His-tagged AKR1B10 expressed in Escherichia coli BL21 using retinaldehyde as substrate	B	7.27	pIC50	54	nM	IC50	J Med Chem (2017) 60: 8441-8455 [PMID:28976752]
ChEMBL	Inhibition of retinaldehyde reductase activity of human AKR1B10	B	7.94	pIC50	11.6	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20764-20769 [PMID:18087047]
Aldo-keto reductase family 1 member C21 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075270] [UniProtKB: Q91WR5]
ChEMBL	Inhibition of mouse recombinant AKR1C21	B	4.66	pKi	22000	nM	Ki	Bioorg Med Chem (2008) 16: 3245-3254 [PMID:18165015]
ChEMBL	Inhibition of mouse recombinant AKR1C21	B	4.32	pIC50	48000	nM	IC50	Bioorg Med Chem (2008) 16: 3245-3254 [PMID:18165015]
aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
ChEMBL	In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determined	B	6.4	pIC50	400	nM	IC50	J Med Chem (2003) 46: 5208-5221 [PMID:14613323]
ChEMBL	Inhibitory Activity against Human recombinant Aldose Reductase (wild type)	B	7.33	pIC50	47	nM	IC50	J Med Chem (2000) 43: 1062-1070 [PMID:10737739]
GtoPdb	-	-	7.33	pIC50	47	nM	IC50	J Med Chem (2000) 43: 1062-70 [PMID:10737739]
ChEMBL	Inhibition of human recombinant aldose reductase	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem (2008) 16: 3245-3254 [PMID:18165015]
ChEMBL	Inhibitory activity against aldose reductase enzyme	B	7.46	pIC50	35	nM	IC50	J Med Chem (2003) 46: 417-426 [PMID:12540241]
ChEMBL	Compound was evaluated In vitro for inhibition of aldose reductase activity by 50% in dog RBC	B	7.62	pIC50	23.9	nM	IC50	J Med Chem (1994) 37: 2043-2058 [PMID:8027986]
ChEMBL	In vitro inhibition of recombinant human aldose reductase expressed in Escherichia coli	B	7.89	pIC50	13	nM	IC50	J Med Chem (2005) 48: 3141-3152 [PMID:15857120]
ChEMBL	Inhibition of N-terminal 6His-tagged human aldose reductase expressed in Escherichia coli BL21(DE3) mediated NADPH linked pyridine-3-aldehyde reduction	B	8	pIC50	10	nM	IC50	Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656]
ChEMBL	Inhibition of human AKR1B1 assessed as decrease in glyceraldehyde reduction	B	8	pIC50	10	nM	IC50	J Med Chem (2017) 60: 8441-8455 [PMID:28976752]
Aldose reductase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4559] [UniProtKB: P80276]
ChEMBL	Inhibition of pig kidney aldose reductase (ALR2)	B	4.8	pIC50	16000	nM	IC50	J Med Chem (2003) 46: 5619-5627 [PMID:14667216]
ChEMBL	Inhibition of aldose reductase from pig lenses	B	7.52	pIC50	30	nM	IC50	J Med Chem (2004) 47: 5076-5084 [PMID:15456251]
ChEMBL	Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrate	B	7.8	pIC50	16	nM	IC50	Bioorg Med Chem Lett (1997) 7: 1677-1682
ChEMBL	In vitro inhibitory activity against aldose reductase in porcine lens.	B	7.82	pIC50	15	nM	IC50	J Med Chem (1998) 41: 4118-4129 [PMID:9767647]
Aldose reductase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3081] [UniProtKB: P16116]
ChEMBL	Evaluated for inhibition of Aldose reductase 2	B	7.02	pIC50	96	nM	IC50	J Med Chem (1996) 39: 4396-4405 [PMID:8893834]
ChEMBL	In vitro inhibition of aldose reductase from the partially purified bovine lens	B	7.46	pIC50	35	nM	IC50	J Med Chem (1990) 33: 2892-2899 [PMID:2120443]
ChEMBL	Inhibition of bovine lens aldose reductase with DL-glyceraldehyde as substrate	B	7.46	pIC50	35	nM	IC50	J Med Chem (1984) 27: 255-256 [PMID:6422042]
ChEMBL	In vitro inhibition of bovine lens aldose reductase	B	7.46	pIC50	35	nM	IC50	J Med Chem (1989) 32: 757-765 [PMID:2539477]
ChEMBL	inhibition of aldose reductase activity was measured on partially purified bovine lens preparations incubated in presence of 50 mM glucose.	B	7.47	pIC50	34	nM	IC50	J Med Chem (1991) 34: 2504-2520 [PMID:1908522]
ChEMBL	In vitro inhibition of aldose reductase in partially purified bovine lens preparation at a concentration of 10e -8M.	B	7.48	pIC50	33	nM	IC50	J Med Chem (1991) 34: 1492-1503 [PMID:1901912]
ChEMBL	In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparation	B	7.48	pIC50	33	nM	IC50	J Med Chem (1994) 37: 2043-2058 [PMID:8027986]
aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943]
ChEMBL	Inhibition of rat AKR1B4	B	6	pIC50	1000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20764-20769 [PMID:18087047]
ChEMBL	In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)	B	6.02	pIC50	950	nM	IC50	J Med Chem (1991) 34: 3229-3234 [PMID:1956041]
ChEMBL	Inhibition of aldose reductase (or polyol accumulation) in isolated rat sciatic nerve by compound at 10e-5 M concentration	B	6.27	pIC50	540	nM	IC50	J Med Chem (1989) 32: 757-765 [PMID:2539477]
ChEMBL	Inhibition of Albino rat eye lens ALR2 assessed as NADPH oxidation by spectrophotometry	B	7.3	pIC50	50	nM	IC50	Eur J Med Chem (2010) 45: 909-914 [PMID:19962793]
ChEMBL	Inhibition of Sprague-Dawley rat lens ALR2 using D,L-glyceraldehyde as substrate preincubated for 10 mins followed by substrate addition measured for 5 mins by spectrophotometric method	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem (2017) 25: 3068-3076 [PMID:28392277]
ChEMBL	In vitro inhibitory activity against aldose reductase (ALR2) from rat lens extraction.	B	7.3	pIC50	50	nM	IC50	J Med Chem (2003) 46: 1419-1428 [PMID:12672241]
ChEMBL	Inhibitory concentration to aldose reductase (ALR-2) obtained from rat lens	B	7.3	pIC50	50	nM	IC50	J Med Chem (2001) 44: 4359-4369 [PMID:11728182]
ChEMBL	In vitro inhibitory activity against aldose reductase (ALR2) from rat lens extraction.	B	7.34	pIC50	46	nM	IC50	J Med Chem (2003) 46: 1419-1428 [PMID:12672241]
ChEMBL	Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrate	B	8.54	pIC50	2.9	nM	IC50	J Med Chem (1991) 34: 1011-1018 [PMID:1900532]
ChEMBL	In vitro inhibition of Aldose reductase (AR) from rat lens (RL)	B	8.7	pIC50	2	nM	IC50	J Med Chem (1991) 34: 3229-3234 [PMID:1956041]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]