Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL1088 (Lidanar, Mesoridazine, NC-123, NSC-186066, Serentil, Thioridazine-2-sulfoxide, TPS-23) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibitory concentration against potassium channel HERG | B | 6.26 | pIC50 | 549.54 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 2886-2890 [PMID:15911273] |
ChEMBL | Inhibition of human Potassium channel HERG expressed in mammalian cells | B | 6.49 | pIC50 | 323.59 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2773-2775 [PMID:12873512] |
ChEMBL | Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique | B | 6.49 | pIC50 | 323.59 | nM | IC50 | Bioorg Med Chem (2008) 16: 6252-6260 [PMID:18448342] |
ChEMBL | Inhibition of human ERG channel | B | 6.49 | pIC50 | 320 | nM | IC50 | J Med Chem (2009) 52: 4266-4276 [PMID:19534531] |
ChEMBL | Inhibition of human ERG channel | B | 6.49 | pIC50 | 320 | nM | IC50 | J Med Chem (2009) 52: 4266-4276 [PMID:19534531] |
ChEMBL | Inhibition of human ERG | B | 6.5 | pIC50 | 316.23 | nM | IC50 | Eur J Med Chem (2011) 46: 618-630 [PMID:21185626] |
5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
GtoPdb | - | - | 6.98 | pKi | 105 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 4379-82 [PMID:15357957] |
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
GtoPdb | - | - | 7.26 | pKi | 55 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 4379-82 [PMID:15357957] |
5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
GtoPdb | - | - | 6.39 | pKi | 412 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 4379-82 [PMID:15357957] |
D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
GtoPdb | - | - | 6.99 | pKi | 103 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 4379-82 [PMID:15357957] |
D2 receptor in Human [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
GtoPdb | - | - | 8.66 | pKi | 2.2 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 4379-82 [PMID:15357957] |
D3 receptor in Human [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
GtoPdb | - | - | 7.64 | pKi | 23 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 4379-82 [PMID:15357957] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]