tecalcet [Ligand Id: 718] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL292376 (Tecalcet) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CaS receptor/Calcium sensing receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1878] [GtoPdb: 54] [UniProtKB: P41180] | ||||||||
| GtoPdb | - | - | 6.5 | pKd | - | - | - | Proc Natl Acad Sci USA (1998) 95: 4040-5 [PMID:9520489] |
| ChEMBL | Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assay | F | 6.71 | pEC50 | 194 | nM | EC50 | J Med Chem (2009) 52: 6535-6538 [PMID:19835382] |
| ChEMBL | Positive allosteric modulation of human CaSR transfected in CHO cells after 5 hrs by luciferase reporter gene assay | B | 7.1 | pEC50 | 80 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 2451-2454 [PMID:23465611] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
