1-arylmethylpyrrolidin-2-yl ethanol amine [Ligand Id: 711] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL200312 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CaS receptor/Calcium sensing receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1878] [GtoPdb: 54] [UniProtKB: P41180] | ||||||||
| ChEMBL | Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPR | F | 6.57 | pIC50 | 270 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 5478-5482 [PMID:16216508] |
| CaS receptor in Rat [GtoPdb: 54] [UniProtKB: P48442] | ||||||||
| GtoPdb | - | - | 4.3 | pIC50 | - | - | - | Bioorg Med Chem Lett (2005) 15: 5478-82 [PMID:16216508] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
